HCV Sequence Locator Tool

Purpose: This tool has several purposes. It can find the start and end coordinates (relative to the reference strain H77) of your input sequence(s) and show which genes or proteins it covers, along with a graphical view of the location of your sequence(s) relative to the reference sequence. The tool will display both the nucleotide sequence and protein translation of your input as it aligns to H77. It will also check the reverse complement of your input sequence, and report the orientation with the best match. Another use is to retrieve a section of the H77 reference sequence based on its coordinates.

How to use: To find the coordinates for your sequence, either upload or paste your sequence (any format) in the box below, or (for database sequences only) enter GenBank accession numbers. To retrieve the H77 sequence for a set of coordinates (see HCV coordinate map), enter the coordinates and choose the region. To retrieve the entire gene or protein, enter coordinate values of "1" and "end". To retrieve a single nucleotide or range with its surrounding 42-nucleotide sequence, enter the single coordinate in the "from" field and check the box. For more details, see Sequence Locator Explanation.

Useful Links:
A comprehensive system for consistent numbering of HCV sequences, proteins and epitopes. Kuiken C et al, Hepatology. 2006 Nov;44(5):1355-61.