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iodine I 131 monoclonal antibody 8H9
A radioimmunoconjugate consisting of the iodine 131-radiolabeled murine IgG1 anti-tenascin monoclonal antibody 8H9 with potential radioimaging and radioimmunotherapeutic uses. Iodine I 131 monoclonal antibody 8H9 binds to the extracellular matrix glycoprotein tenascin-C and may be used to radioimage and/or destroy tumor cells that express tenascin. Tenascin-C (Tn-C; hexabrachion; cytotactin) is a disulfide-bonded hexamer composed of subunits with molecular weights in the range of 120–300 kDa and is found in many solid tumors, including breast cancers, gliomas, sarcomas, and neuroblastomas. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| Abbreviation: | | iodine I 131 MOAB 8H9 | | |
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