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medroxyprogesterone A synthetic derivative of progesterone administered as an acetate salt (medroxyprogesterone acetate) with antiestrogenic activity. As a do all progestins, medroxyprogesterone binds to and activates nuclear receptors which subsequently bind to and activate target genes for transcription. As an antiestrogen, this agent may inhibit the growth-stimulating effects of estrogen on estrogen-sensitive tumor cells. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090114230500im_/http://www.cancer.gov/images/spacer.gif) | medroxyprogesterone acetate | | ![](https://webarchive.library.unt.edu/eot2008/20090114230500im_/http://www.cancer.gov/images/spacer.gif) | US brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090114230500im_/http://www.cancer.gov/images/spacer.gif) | Curretab Depo-Provera Provera Provera Dosepak | | ![](https://webarchive.library.unt.edu/eot2008/20090114230500im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090114230500im_/http://www.cancer.gov/images/spacer.gif) | MPA | | ![](https://webarchive.library.unt.edu/eot2008/20090114230500im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20090114230500im_/http://www.cancer.gov/images/spacer.gif) | - (6alpha)-17-hydroxy-6-methylpregn-4-ene-3,20-dione
- 17alpha-hydroxy-6alpha-methylprogesterone
- 6alpha-methyl-17alpha-hydroxyprogesterone
- 6alpha-methyl-4-pregnen-17alpha-ol-3,20-dione
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