Multicentric reticulohistiocytosis
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Multicentric reticulohistiocytosis is a disease that is characterized by the presence of papules and nodules and associated with arthritis mutilans.[1] The disease can involve the skin, the bones, the tendons, the muscles, the joints, and nearly any other organ (e.g., eyes, larynx, thyroid, salivary glands, bone marrow, heart, lung, kidney, liver, gastrointestinal tract). In the majority of cases, the cause of multicentric reticulohistiocytosis is unknown; however, it has been associated with an underlying cancer in about one fourth of cases, suggesting that it may be a paraneoplastic syndrome.[2][3]
References
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Chakravarty EF, Genovese MC. Harris: Kelley’s Textbook of Rheumatology, 7th ed.. In: . Chapter 111 -- Musculoskeletal Syndromes in Malignancy. Philadelphia, PA:W.B. Saunders Company; 2005:
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West SG. Goldman: Cecil Textbook of Medicine, 23rd ed.. In: . Chapter 297 -- Systemic Diseases in Which Arthritis is a Feature. Philadelphia, PA:Saunders Elsevier; 2008:
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Rapini RP. Multicentric Reticulohistiocytosis. eMedicine . March 10, 2008 Available at: http://www.emedicine.com/derm/topic276.htm. Accessed March 11, 2008.
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