Chromatin Organization, Non-Coding RNAs and Dosage Compensation in Drosophila |
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| Launch in standalone player | |
| Air date: | Wednesday, January 25, 2006, 3:00:00 PM |
| Category: | Wednesday Afternoon Lectures |
| Description: | MSL proteins and noncoding roX RNAs form complexes that bind hundreds of sites along the single male X chromosome to make X-linked gene expression equal in male and female Drosophila. MSL complexes are proposed to up-regulate X-linked genes through site-specific acetylation of histone H4 at Lys16. The roX1 and roX2 RNAs are dissimilar in size and sequence, but are functionally redundant. The roX RNAs are required for normal targeting of the X chromosome, and in their absence MSL complexes bind poorly to the X.
For more information, visit http://www.hms.harvard.edu/dms/bbs/fac/kurodami.html The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide. |
| Author: | Mitzi Kuroda, Harvard Medical School |
| Runtime: | 60 minutes |
| Download: | Download
Video How to download a Videocast |
| CIT File ID: | 13025 |
| CIT Live ID: | 4259 |
| Permanent link: | http://videocast.nih.gov/launch.asp?13025 |