Inclusion Criteria:

Pts have histologically confirmed diagnosis of recurrent/progressive WHO grade IV MG

• Age >18 yrs
• No prior treatment w bortezomib, & no Avastin in <3 mths, not allowed to have progressed to Avastin regimen. No history of >gr 2 CNS hemorrhage,/gr3 / >toxicities while on Avastin
• <6wks from surgical resection, 4 wks from end of XRT & enrollment in this study
• KPS>70
• Hgb >9 g/dL, ANC >1,500 cells/microliter, platelets >125,000 cells/microliter;
• Serum creatinine <1.5 mg/dl, serum SGOT & bilirubin <1.5 x ULN
• Signed informed consent approved by IRB;
• If sexually active, pts must agree to take contraceptive measures for duration of treatments
• May have had up to 3 biological therapies

Exclusion Criteria:

• Gr 2/ >peripheral neuropathy at time of study enrollment
• No prior taxanes, as it predisposes to sensory neuropathy

• Co-medication that may interfere w study result

  •>3 prior recurrences

• Evidence of CNS hemorrhage on baseline MRI on CT scan
• History of thrombotic/hemorrhagic stroke/myocardial infarction <6 mths

• Requires therapeutic anti-coagulation

  •>4 wks from Day 0 of prior monthly chemo. >1 wk from last dose of daily chemo / targeted therapies administered daily

• Pregnancy/breast feeding
• Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection requiring IV antibiotics & psychiatric illness/social situations that would limit compliance w study requirements,/disorders associated w significant immunocompromised state
• Pts w another primary malignancy that has required treatment within past year. Avastin-Specific Concerns
• Any prior history of hypertensive crisis/hypertensive encephalopathy
• Systolic BP >150 mmHg/diastolic BP >100 mmHg
• Unstable angina
• New York Heart Association Gr II />congestive heart failure
• History of myocardial infarction within 6 mths
• History of stroke within 6 mths
• Clinically significant peripheral vascular disease
• Evidence of bleeding diathesis, coagulopathy as documented by an elevated PT, PTT/bleeding time
• Major surgical procedure, open biopsy,/significant traumatic injury <28 days prior to Day 0, anticipation of need for major surgical procedure during course of study
• Minor surgical procedures, fine needle aspirations/core biopsies <7 days prior to Day 0
• Urine protein: creatinine ratio >1.0 at screening
• History of abdominal fistula, GI perforation,/intra-abdominal abscess <6 months prior to Day 0
• Serious, non-healing wound, ulcer,/bone fracture
• Known hypersensitivity to any component of Avastin
• Inability to comply w study and/or follow-up procedures