National Toxicology Program

Documents may also be found via the Agency Guidelines and Regulations Search Page

Consumer Product Safety Commission (CPSC)

• U.S. Code of Federal Regulations (CFR)
  • 16 CFR 1500 - Hazardous Substances and Articles; Administration and Enforcement Regulations
    • 16 CFR 1500.3 - Definitions (includes definitions for "hazardous substances", "corrosive", "irritant", etc.) [PDF]
    • 16 CFR 1500.4 - Human experience with hazardous substances [PDF]
    • 16 CFR 1500.41 - Method of testing primary irritant substances [PDF]

U.S. Department of Transportation (DOT) Regulations

• Exemption DOT-E-10904 (Seventh Revision) - Allows use of Corrositex® as alternative test method [PDF]
• Code of Federal Regulations:
  • 49 CFR 172.442 - Hazardous Materials: Labeling of Corrosive Substances - Placement [PDF]
  • 49 CFR 172.558 - Hazardous Materials: Labeling of Corrosive Substances - Appearance [PDF]
  • 49 CFR 173.136 - General Requirements for Shipments and Packagings: Class 8 Definitions (criteria for determining classifications of corrosive materials) [PDF]
  • 49 CFR 173.137 - General Requirements for Shipments and Packagings: Assignment of packing group and hazard zones for Division 8 materials (corrosives and irritants) [PDF]

U.S. Environmental Protection Agency (EPA)

• EPA Test Method 1120 - Dermal Corrosion [PDF]
• Office of Prevention, Pesticides and Toxic Substances Health Effects Test Guideline: OPPTS 870.2500 - Acute Dermal Irritation (August 1998) [PDF]
• Code of Federal Regulations:
  • 40 CFR 152.170 - Criteria for restriction to use by certified applicators (criteria includes corrosivity) [PDF]
  • 40 CFR 156.10 - Labeling requirements (skin corrosives are in toxicity category I) [PDF]
  • 40 CFR 157 (Subpart B) - Child-Resistant Packaging (157.22 pesticides corrosive to eyes or skin) [PDF]
  • 40 CFR 261.22 - Characteristic of Corrosivity [PDF]

Organisation for Economic Co-operation and Development (OECD)

• OECD Guideline for the Testing of Chemicals Number 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (April 13, 2004) [PDF]
• OECD Guideline for the Testing of Chemicals Number 431: In Vitro Skin Corrosion: Human Skin Model Test (April 13, 2004) [PDF]
• OECD Guideline for the Testing of Chemicals Number 435: In Vitro Membrane Barrier Test Method for Skin Corrosion (July 19, 2006) [PDF]

U.S. Occupational Safety and Health Adminstration

• Code of Federal Regulations:
  • 29 CFR 1910.1200 - Hazard Communication
    Appendix A (pg 473)- Health Hazard Definitions (definition of corrosive is item 2 of Appendix A) [PDF]