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Sponsored by: |
Department of Veterans Affairs |
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Information provided by: | Department of Veterans Affairs |
ClinicalTrials.gov Identifier: | NCT00108498 |
This study will determine if mirtazapine, a unique antidepressant that does not disturb sleep, will improve obstructive sleep apnea (OSA). The design is randomized, crossover, double blind, and placebo controlled. On two consecutive nights of one week, the patients receive either 30 mg mirtazapine or placebo at bedtime. The following week, the alternative medication is administered. The patients have known mild to moderate sleep apnea. The endpoints of the study are the apnea + hypopnea index (AHI), sleep quality, and the degree of arterial oxygen desaturation.
Condition | Intervention | Phase |
---|---|---|
Obstructive Sleep Apnea |
Drug: mirtazapine |
Phase I |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Crossover Assignment, Efficacy Study |
Official Title: | New Pharmacological Treatment for Obstructive Sleep Apnea |
Ages Eligible for Study: | 20 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Study ID Numbers: | RESP-011-02F |
Study First Received: | April 15, 2005 |
Last Updated: | May 15, 2007 |
ClinicalTrials.gov Identifier: | NCT00108498 |
Health Authority: | United States: Federal Government |
sleep apnea mirtazapine sleep |
Sleep Apnea Syndromes Apnea Sleep Apnea, Obstructive Respiration Disorders Sleep Disorders Dyssomnias Mirtazapine |
Sleep Disorders, Intrinsic Histamine Signs and Symptoms Respiratory Tract Diseases Signs and Symptoms, Respiratory Histamine phosphate |
Neurotransmitter Agents Adrenergic Agents Molecular Mechanisms of Pharmacological Action Nervous System Diseases Physiological Effects of Drugs Psychotropic Drugs Histamine Agents Adrenergic alpha-Antagonists |
Pharmacologic Actions Antidepressive Agents, Tricyclic Histamine Antagonists Therapeutic Uses Histamine H1 Antagonists Adrenergic Antagonists Central Nervous System Agents Antidepressive Agents |