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troxacitabine
A dioxolane derivative and a novel L-configuration deoxycytidine analogue with potent antineoplastic activity. When incorporated into growing chain during DNA replication, troxacitabine stops DNA polymerization due to its unnatural L-configuration, in contrast to the normal nucleotides with D-configuration. As a result, this agent terminates DNA synthesis upon incorporated into DNA molecules, and consequently interrupts tumor cell proliferation. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
| US brand name: | | Troxatyl | | | | Code names: | | BCH-4556
L-Oddc | | | | Chemical structure name: | | 2(1H)-Pyrimidinone, 4-amino-1-((2S,4S)-2-(hydroxymethyl)-1,3-dioxolan-4-yl)- | | |
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