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TNP-470 A synthetic analog of fumagillin, an antibiotic isolated from the fungus Aspergillus fumigatus fresenius with antineoplastic activity. TNP-470 binds to and irreversibly inactivates methionine animopeptidase-2 (MetAP2), resulting in endothelial cell cycle arrest late in the G1 phase and inhibition of tumor angiogenesis. This agent may also induce the p53 pathway, thereby stimulating the production of cyclin-dependent kinase inhibitor p21 and inhibiting angiogenesis. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Code name: | ![](https://webarchive.library.unt.edu/eot2008/20090115030311im_/http://www.cancer.gov/images/spacer.gif) | AGM-1470 | | ![](https://webarchive.library.unt.edu/eot2008/20090115030311im_/http://www.cancer.gov/images/spacer.gif) | Chemical structure names: | ![](https://webarchive.library.unt.edu/eot2008/20090115030311im_/http://www.cancer.gov/images/spacer.gif) | - (3R,4S,5S,6R)-5-methoxy-4- [(2R,3R)-2-methyl-3-(3-methyl-2-butenyl) -oxiranyl]-1-oxaspiro [2,5] oct-6-yl(chloroacetyl) carbamate
- 5-methoxy-4-(2-methyl-3-(3-methyl-2-butenyl)-1-oxaspiro(2,5)oct-6-yl(chloroacetyl) carbamate
- O-(chloroacetylcarbamoyl)fumagillol
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