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anti-thymocyte globulin A purified gamma immunoglobulin (IgG) with immunosuppressive activity. Obtained from rabbits that have been immunized with human thymocytes, antithymocyte globulin specifically recognizes and destroys T lymphocytes. Although the exact mechanism of action is not completely understood, it appears to involve T lymphocyte clearance from the circulation and modulation of T lymphocyte activity. Administering antithymocyte globulin with chemotherapy prior to stem cell transplantation may reduce the risk of graft-versus-host disease. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)
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Synonym: | ![](https://webarchive.library.unt.edu/eot2008/20090115032120im_/http://www.cancer.gov/images/spacer.gif) | lymphocyte immune globulin | | ![](https://webarchive.library.unt.edu/eot2008/20090115032120im_/http://www.cancer.gov/images/spacer.gif) | US brand names: | ![](https://webarchive.library.unt.edu/eot2008/20090115032120im_/http://www.cancer.gov/images/spacer.gif) | ATGAM Thymoglobulin | | ![](https://webarchive.library.unt.edu/eot2008/20090115032120im_/http://www.cancer.gov/images/spacer.gif) | Abbreviation: | ![](https://webarchive.library.unt.edu/eot2008/20090115032120im_/http://www.cancer.gov/images/spacer.gif) | ATG | | ![](https://webarchive.library.unt.edu/eot2008/20090115032120im_/http://www.cancer.gov/images/spacer.gif) |
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