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| Sponsored by: |
Hadassah Medical Organization |
|---|---|
| Information provided by: | Hadassah Medical Organization |
| ClinicalTrials.gov Identifier: | NCT00159029 |
Purpose
Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.
We are analyzing the alpha globin genes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.
| Condition |
|---|
|
Alpha Thalassemia |
| Study Type: | Observational |
| Official Title: | Haplotype Analysis of Alpha Globin Genes in Israeli Ethnic Groups |
DNA isolated from peripheral blood.
| Estimated Enrollment: | 100 |
| Study Start Date: | April 2004 |
| Estimated Study Completion Date: | April 2009 |
Alpha thalassemia causes mild anemia and is found in many ethnic groups. Usually it is found in regions where malaria is endemic. We have found that alpha thalassemia is common in Ashkenazim, whose countries of origin are in temperate climates.
We are analyzing the alpha globin polymorphisms to determine the haplotypes of individuals of many ethnic groups and will compare to try to define the origin of thalassemia in these individuals of European extraction.
Eligibility| Ages Eligible for Study: | 18 Years and older |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
| Sampling Method: | Non-Probability Sample |
Patients who come to Hadassah Hospital for anemia with microcytosis who are found to have alpha thalassemia.
Inclusion Criteria:
Exclusion Criteria:
Contacts and Locations| Contact: Deborah Rund, MD | 00 972 2 6778712 | rund@cc.huji.ac.il |
| Contact: Hadas Lemberg, PhD | 00 972 2 6777572 | lhadas@hadassah.org.il |
| Israel | |
| Hadassah Medical Organization | Recruiting |
| Jerusalem, Israel | |
| Contact: Arik Tzukert, DMD 00 972 2 6776095 arik@hadassah.org.il | |
| Contact: Hadas Lemberg, PhD 00 972 2 6777572 lhadas@hadassah.org.il | |
| Principal Investigator: Deborah Rund, MD | |
| Principal Investigator: | Deborah Rund, MD | Hadassah Medical Organization |
More Information
| Responsible Party: | Hadassah Medical Organization ( Deborah Rund ) |
| Study ID Numbers: | 152910-HMO-CTIL |
| Study First Received: | September 9, 2005 |
| Last Updated: | December 17, 2007 |
| ClinicalTrials.gov Identifier: | NCT00159029 |
| Health Authority: | Israel: Israeli Health Ministry Pharmaceutical Administration |
|
Anemia, Hemolytic, Congenital Genetic Diseases, Inborn Hematologic Diseases Hemoglobinopathies Anemia |
Anemia, Hemolytic Hemoglobinopathy Thalassemia Alpha-Thalassemia |
