The Registry of Toxic Effects of Chemical Substances

Osmium tetroxide

RTECS #: RN1140000

CAS #: 20816-12-0

UPDATE: May 2008 MW: 254.20 MF: O4Os


NOTE:

TABLE OF CONTENTS:
  1. SYNONYMS:
  2. MUTATION DATA:
  3. REPRODUCTIVE EFFECTS DATA:
  4. ACUTE TOXICITY DATA:
  5. REVIEWS:
  6. STANDARDS AND REGULATIONS:
  7. NIOSH DOCUMENTATION AND SURVEILLANCE:
  8. STATUS IN FEDERAL AGENCIES:
  9. REFERENCES:

SYNONYMS:

  1. Osmic acid
  2. Osmium tetroxide (ACGIH:OSHA)
  1. Osmium (VIII) oxide
  2. RCRA waste number P087


SKIN AND EYE IRRITATION DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


MUTATION DATA AND REFERENCES:

SYSTEM TEST ROUTE/
ORGANISM/
TISSUE 		DOSE REFERENCE
DNA repair Bacillus subtilis 5 mmol/L MUREAV 77,109,1980
unscheduled DNA synthesis hamster embryo 200 µmol/L MUREAV 131,173,1984


REPRODUCTIVE EFFECTS DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
intratesticular
rat 		lowest published toxic dose: 20,336 µg/kg (1 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JRPFA4 7,21,1964
subcutaneous
mouse 		lowest published toxic dose: 20,336 µg/kg (30 day male) Reproductive: Paternal effects: Spermatogenesis (including genetic material, sperm morphology, motility, and count)

Reproductive: Paternal effects: Testes, epididymis, sperm duct 		JRPFA4 7,21,1964


TUMORIGENIC DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


ACUTE TOXICITY DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
inhalation
man 		lowest published toxic concentration: 133 µg/m3 Eye: Lacrimation

Eye: Other eye effects

Lung, Thorax, or Respiration: Structural or functional change in trachea or bronchi 		BJIMAG 3,183,1946
inhalation
mouse 		lowest published lethal concentration: 40 ppm/4 hour N/R SCCUR* -,8,1961
inhalation
rat 		lowest published lethal concentration: 40 ppm/4 hour N/R SCCUR* -,8,1961
inhalation
rabbit 		lowest published lethal concentration: 1,316 mg/m3/30 minute Behavioral: Coma

Lung, Thorax, or Respiration: Other changes

Kidney, Ureter, and Bladder: Other changes 		JIDHAN 15,136,1933
intraperitoneal
mouse 		lethal dose (50 percent kill): 13,500 µg/kg N/R SCCUR* -,8,1961
intraperitoneal
rat 		lethal dose (50 percent kill): 14,100 µg/kg N/R SCCUR* -,8,1961
ocular
rabbit 		lowest published toxic dose: 0.25 mg/kg Eye: Corneal damage VCVN5* -,526,1989
oral
mouse 		lethal dose (50 percent kill): 162 mg/kg N/R SCCUR* -,8,1961


OTHER MULTIPLE DOSE DATA AND REFERENCES:

ROUTE/
ORGANISM 		DOSE
EFFECT

 REFERENCE
N/R
 N/R N/R N/R


REVIEWS:

ORGANIZATION STANDARD
REFERENCE
American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value time-weighted average 0.0002 ppm;short term exposure limit 0.0006 ppm DTLVS* TLV/BEI,2007


STANDARDS AND REGULATIONS:

ORGANIZATION STANDARD
REFERENCE
Mine Safety and Health Administration (MSHA) STANDARD - air time-weighted average 0.002 mg/m3 DTLVS* 3,192,1971
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (General Industry) 8 hour time-weighted average 0.002 mg(Os)/m3 CFRGBR 29,1910.1000,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Construction) 8 hour time-weighted average 0.002 mg(Os)/m3 CFRGBR 29,1926.55,1994
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Shipyards) 8 hour time-weighted average 0.002 mg(Os)/m3 CFRGBR 29,1915.1000,1993
Occupational Safety and Health Administration (OSHA) Permissible Exposure Limit (Federal Contractors) 8 hour time-weighted average 0.002 mg(Os)/m3 CFRGBR 41,50-204.50,1994
Occupational Exposure Limit - ARAB Republic of Egypt time-weighted average 0.0002 ppm (0.002 mg/m3), JAN1993
Occupational Exposure Limit - AUSTRALIA time-weighted average 0.0002 ppm (0.002 mg/m3), short term exposure limit 0.0006 ppm, JAN1993
Occupational Exposure Limit - BELGIUM time-weighted average 0.0002 ppm (0.0016 mg/m3), short term exposure limit 0.0006 ppm, JAN1993
Occupational Exposure Limit - DENMARK time-weighted average 0.0002 ppm (0.002 mg(Os)/m3), OCT 2002
Occupational Exposure Limit - FINLAND time-weighted average 0.0002 mg/m3, short term exposure limit 0.002 mg/m3, JAN1999
Occupational Exposure Limit - FRANCE VME 0.0002 ppm (0.002 mg/m3), FEB2006
Occupational Exposure Limit - GERMANY MAK 0.0021 mg(Os)/m3 (0.0002 mL(Os)/m3), 2005
Occupational Exposure Limit - KOREA time-weighted average 0.0002 ppm (0.0002 mg/m3), short term exposure limit 0.0006 ppm (0.0006 mg/m3), 2006
Occupational Exposure Limit - MEXICO time-weighted average 0.0002 ppm;
short term exposure limit 0.0006 ppm, 2004
Occupational Exposure Limit - THE NETHERLANDS MAC-TGG 0.002 mg/m3, 2003
Occupational Exposure Limit - NEW ZEALAND time-weighted average 0.0002 ppm (0.0016 mg/m3), JAN2002
Occupational Exposure Limit - NORWAY time-weighted average 0.0002 ppm (0.002 mg/m3), JAN1999
Occupational Exposure Limit - THE PHILIPPINES time-weighted average 0.002 mg/m3, JAN1993
Occupational Exposure Limit - SWITZERLAND MAK- week 0.0002 ppm (0.002 mg(Os)/m3),KZG- week 0.002 mg(Os)/m3, DEC2006
Occupational Exposure Limit - UNITED KINGDOM time-weighted average 0.0002 ppm;
short term exposure limit 0.0006 ppm, 2005
Occupational Exposure Limit IN ARGENTINA, BULGARIA, COLOMBIA, JORDAN American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value;

time-weighted average 0.0002 ppm;
short term exposure limit 0.0006 ppm
Occupational Exposure Limit IN SINGAPORE, VIETNAM American Conference of Governmental Industrial Hygienists (ACGIH) Threshold Limit Value
time-weighted average 0.0002 ppm;
short term exposure limit 0.0006 ppm


NIOSH DOCUMENTATION AND SURVEILLANCE:

ORGANIZATION STANDARD or SURVEY
REFERENCE
National Institute for Occupational Safety and Health (NIOSH) Recommended Exposure Level TO OSMIUM TETROXIDE-air 10 hour time-weighted average 0.0002 ppm;
short term exposure limit 0.0006 ppm 		NIOSH* DHHS #92-100,1992
National Occupational Hazard Survey 1974 National Occupational Hazard Survey 1974: Hazard Code: 52370;
Number of Industries 2;
Total Number of Facilities 195;
Number of Occupations 2;
Total Number of Employees Exposed 370
National Occupational Exposure Survey 1983 National Occupational Exposure Survey 1983: Hazard Code: 52370;
Number of Industries 2;
Total Number of Facilities 87;
Number of Occupations 5;
Total Number of Employees Exposed 1,733;
Total Number of Female Employees Exposed 420


STATUS IN FEDERAL AGENCIES:

ORGANIZATION
REFERENCE
EPA GENETOX PROGRAM 1988, Positive: B subtilis rec assay
EPA GENETOX PROGRAM 1988, Inconclusive: D melanogaster Sex-linked lethal
EPA TSCA Section 8(b) CHEMICAL INVENTORY
Used as catalyst, fixative and oxidizing agent
On EPA IRIS database


REFERENCES:

CODEN
REFERENCE
BJIMAG British Journal of Industrial Medicine. (British Medical Journal, Box 560B, Kennebunkport, ME 04046) V.1- 1944-
CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402)
DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996
JIDHAN Journal of Industrial Hygiene. (Cambridge, MA) V.1-17, 1919-35. For publisher information, see AEHLAU.
JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960-
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964-
NIOSH* National Institute of Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda.
SCCUR* Shell Chemical Company. Unpublished Report. (2401 Crow Canyon Rd., San Romon, CA 94583)
VCVN5* "Vrednie chemichescie veshestva. Neorganicheskie soedinenia elementov V-VII groopp" (Hazardous substances. Inornanic substances containing V-VII group elements), Bandman A.L. et al., Chimia, 1989.

Used as catalyst, fixative and oxidizing agent

RTECS Compound Description:
   Drug
   Mutagen
   Reproductive Effector
   Human Data

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