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Sponsored by: |
University Hospital, Tours |
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Information provided by: | University Hospital, Tours |
ClinicalTrials.gov Identifier: | NCT00288314 |
Neuropsychological studies investigating trauma-exposed and posttraumatic stress disorder (PTSD) subjects have generally underlined the significantly poorer performance of tasks that require attention, concentration, and verbal memory, and difficulty in regulating memories surrounding the traumatic event. A previous study (El Hage et al. Cognitive Neuropsychiatry, 2006) revealed that the trauma-exposed subjects scored higher on anxiety/depression scales, and lower on processing speed tests. Moreover, the study showed significant impairment in working memory partially mediated by speed processing, but not by anxiety or depression. These results suggest that processing speed makes a major contribution to trauma-related working memory decline, and needs to be investigated in further studies.The aim of the present study is to explore correlation between hippocampus volume, frontal dysfunction and cognitive slowing in trauma-exposed subjects, while examining brain activation during performance of working memory tasks using functional magnetic resonance.
Condition | Intervention |
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Post-Traumatic Stress Disorders Anxiety Amnesia, Dissociative |
Procedure: Magnetic Resonance Imaging, Functional |
Study Type: | Observational |
Study Design: | Natural History, Cross-Sectional, Case Control, Retrospective/Prospective Study |
Official Title: | Working Memory Updating in Posttraumatic Stress Disorder (PTSD): Study of Neural Correlates Using fMRI |
Estimated Enrollment: | 18 |
Study Start Date: | January 2007 |
Estimated Study Completion Date: | May 2008 |
Working memory performance will be assessed using the “3-back test”, and processing speed evaluated with “words comparison test”. The study will be conducted on 2 years. The study should include 18 right-handed females victims of sexual abuse and suffering from PTSD, and 18 controls right-handed females without any history of abuse ad not suffering from PTSD. Brain activation will be measured during performance of working memory tasks (3-back test) and processing speed test using functional magnetic resonance.
Ages Eligible for Study: | 18 Years to 40 Years |
Genders Eligible for Study: | Female |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Exclusion Criteria:
Contact: Wissam EL HAGE, MD, PhD | +33613218116 | el-hage@med.univ-tours.fr |
France, CENTRE | |
University Hospital of Tours | Recruiting |
TOURS, CENTRE, France, 37044 | |
Sub-Investigator: VINCENT CAMUS, PR | |
Sub-Investigator: CHRISTOPHE DESTRIEUX, MD, PhD | |
Sub-Investigator: JEAN-PHILIPPE COTTIER, PR | |
Sub-Investigator: CAROLINE HOMMET, MD, PhD | |
Sub-Investigator: CATHERINE BELZUNG, PR | |
Sub-Investigator: MICHEL ISINGRINI, PR | |
Sub-Investigator: JOELLE MARTINEAU, PhD | |
Sub-Investigator: DAVID CLARYS, PhD | |
Sub-Investigator: LAURENCE TACONNAT, PhD | |
Principal Investigator: WISSAM EL HAGE, MD, PhD |
Principal Investigator: | Wissam EL HAGE, MD, PhD | UNIVERSITY HOSPITAL OF TOURS |
Study ID Numbers: | PHRR04-WEH/METRAPI |
Study First Received: | February 3, 2006 |
Last Updated: | July 4, 2007 |
ClinicalTrials.gov Identifier: | NCT00288314 |
Health Authority: | France: National Consultative Ethics Committee for Health and Life Sciences |
PTSD MRI, Functional Anxiety Working Memory Processing speed |
Stress Memory Disorders Stress Disorders, Traumatic Cognition Disorders Signs and Symptoms Methamphetamine Delirium, Dementia, Amnestic, Cognitive Disorders Anxiety Disorders |
Mental Disorders Stress Disorders, Post-Traumatic Neurologic Manifestations Amphetamine Dementia Neurobehavioral Manifestations Amnesia Delirium |
Pathologic Processes Disease Nervous System Diseases |