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Sponsored by: |
National Institute on Deafness and Other Communication Disorders (NIDCD) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001308 |
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal biochemical and metabolic processes of the central nervous system of normal individuals and patients with neurologic illnesses without physical / structural damage to the brain. Radioactive water H215O in PET scans permits good visualization of areas of the brain related to speech.
Most of the PET scan studies conducted have concentrated on learning about how language is formed and decoded. Few studies have been conducted on speech production. This study aims to use radioactive water (H215O) and Positron Emission Tomography (PET scan) to measure blood flow to different areas of the brain in order to better understand the mechanisms involved in speech motor control.
When a region of the brain is active, it uses more fuel in the form of oxygen and sugar (glucose). As the brain uses more fuel it produces more waste products, carbon dioxide and water. Blood carries fuel to the brain and waste products away from the brain. As brain activity increases blood flow to and from the area of activity increases also. Knowing these facts, researchers can use radioactive chemicals (H215O) and PET scans to observe what areas of the brain are receiving more blood flow.
Researchers will ask patients to perform tasks that will affect speech, voice, and language. At the same time patients will undergo a PET scan. The tasks are designed to help researchers observe the blood flow to brain areas associated with voicebox (laryngeal) functions, movement of muscles in the jaw, tongue, and mouth, and other aspects of motor speech.
Special studies will be conducted to evaluate how certain therapies and tasks can draw out symptoms in illnesses in which speech and language are affected. Results of these tests will be used in other studies to evaluate the neurologic mechanisms of diseases like Tourette's syndrome and parkinson's disease.
Condition |
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Communication Disorder Healthy Stuttering Tourette Syndrome Voice Disorder |
Study Type: | Observational |
Official Title: | Multimodal Studies of Language Production and Comprehension in Normal Volunteers and Patients With Neurologically-Based Language Impairments |
Estimated Enrollment: | 1127 |
Study Start Date: | April 1992 |
The H215O PET, fMRI, and EEG neuroimaging method will be used to study the CNS mechanisms involved in speech production. Sets of controlled tasks intended to isolate and activate distinct elements of motor speech and voice will be administered to normal controls and patients with speech disorders. Individual scans will generally be performed during each task condition. Arterial blood will be sampled to permit full quantification of the PET data.
Generalized tasks will be administered both to normal controls and patients with neurological disorders affecting speech, voice and language. These tasks are designed to evaluate the regional cerebral blood flow patterns associated with elementary laryngeal functions, oral, lingual and jaw movements, as well as linguistic and non-linguistic speech production. Other generalized tasks will evaluate prosodic and affective elements of motor speech, premotor mechanisms in speech motor control and regional cerebral blood flow correlates of speech learning.
A separate series of studies will evaluate therapeutic interventions or behavioral tasks designed to attenuate symptoms in illnesses in which speech and language are affected. These will be utilized in a repeated measures design to evaluate CNS mechanisms underlying dysfluency in patients with stuttering, and limb vs. speech motor symptoms in Tourette's syndrome, Parkinson's disease, stroke and other neurological disorders.
Ages Eligible for Study: | 18 Years to 80 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Subjects will be selected from a population of patients with post-stroke aphasia.
No preference or exclusion will be granted due to gender, religion, race or ethnic background.
Non-pregnant, non-breast feeding, age and sex matched normal subjects will be recruited to provide control values.
Recruitment will be limited to those 18 years to 80 years in age.
EXCLUSION CRITERIA:
Children will be excluded form this protocol because they do not represent members of the population at risk.
Pregnant women are excluded because the effects of the MRI on the fetus have not been established.
Contact: Patient Recruitment and Public Liaison Office | (800) 411-1222 | prpl@mail.cc.nih.gov |
Contact: TTY | 1-866-411-1010 |
United States, Kansas | |
University of Kansas | Recruiting |
Kansas City, Kansas, United States, 66160 | |
United States, Maryland | |
Suburban Hospital | Recruiting |
Bethesda, Maryland, United States, 20814 | |
United States, Oregon | |
Oregon Health Sciences University | Recruiting |
Portland, Oregon, United States, 97201-3098 |
Study ID Numbers: | 920178, 92-DC-0178 |
Study First Received: | November 3, 1999 |
Last Updated: | November 7, 2008 |
ClinicalTrials.gov Identifier: | NCT00001308 |
Health Authority: | United States: Federal Government |
Stuttering Tourette's Syndrome Spasmodic Dysphonia Dysarthria Parkinson's Disease |
Verbal Dyspraxia Aphasia Speech Motor Control |
Basal Ganglia Diseases Apraxia Healthy Brain Diseases Neurodegenerative Diseases Tics Signs and Symptoms Heredodegenerative Disorders, Nervous System Respiratory Tract Diseases Mental Disorders Movement Disorders Mental Disorders Diagnosed in Childhood Laryngeal Diseases Apraxias Neurobehavioral Manifestations |
Speech Disorders Otorhinolaryngologic Diseases Ganglion Cysts Spastic dysphonia Aphasia Language Disorders Central Nervous System Diseases Tourette Syndrome Tic Disorders Spasmodic dysphonia Genetic Diseases, Inborn Parkinson Disease Dysarthria Neurologic Manifestations Gilles de la Tourette's syndrome |
Pathologic Processes Disease Syndrome Nervous System Diseases |