- Abernethy DR: Aging: Its influence on drug disposition and effect. In: Nephrology and Geriatrics Integrated, DG Oreopoulos, WR Hazzard, and R Luke (Eds.) Kluwer Academic Publishers, Boston 2000; pp 37-45.
- Abernethy DR, Flockhart DA: Molecular basis of cardiovascular drug metabolism: Implications for predicting clinically important drug interactions. Circulation 2000; 101:1 749-1753.
- Abernethy DR, Wainer IW, and Anacleto AI: Verapamil metabolite exposure in older and younger men during steady-state oral verapamil administration. Drug Metab Dispos 2000; 28: 760-765.
- Andrawis NS, Battle MM, Klamerus KJ, Burghart PH, Neefe L, Weinryb I, Mayer P, Abernethy DR: A pharmacokinetic and pharmacodynamic study of the potential drug interaction between tasosartan and atenolol in patients with stage 1 and 2 essential hypertension. J Clin Pharmacol 2000; 40: 231-241.
- Andrawis N, Jones DS, Abernethy DR: Aging is associated with endothelial dysfunction in the human forearm vasculature. J Am Geriatr Soc 2000; 48: 193-198.
- Andrisano V, Bertucci C, Cavrini V, Varoli L, Felix G, and Wainer IW: Stereoselective binding of 2,3-substituted-3-hydroxy-propionic acids on an immobilized human serum albumin chiral stationary phase: Stereochemical characterization and QSSR study. J Chromatogr A 2000; 876: 75-86.
- Aspelund G, Egan JM, Slezak LA, Sritharan KC, Elahi DE, Andersen DK: Glucagon like peptide-1 and exendin-4 improve glucose tolerance and induce islet cell growth during chronic pancreatitis in rats. Surgical Forums 2000; L1: 40-42.
- Auclair B, Wainer IW, Fried K, Koch P, Jerussi TP, and Ducharme MP: A population analysis of nebulized (R)-albuterol in dogs using a novel mixed gut-lung absorption PK-PD model. Pharm Res 2000; 17: 1228-1235.
- Bendriss E-K, Markoglou N, and Wainer IW: A liquid chromatographic method for the simultaneous determination of caffeine and fourteen caffeine metabolites in urine. J. Chromatogr B 2000; 746: 331-338.
- Bosco MC, Curiel R, Zea A, Malabarba MG, Ortaldo JR, and Espinoza-Delgado I: IL-2 signaling in human monocytes involves the phosphorylation and activation of p59hck. J Immunol 2000; 164: 4575.
- *Clocquet AR, *Egan JM, *Stoffers DA, (*equal contributors) Muller DC, Wideman L, Chin GA, Clarke WL, Hanks JB, Habener JF, Elahi D: Impaired insulin secretion and increased insulin sensitivity in familial MODY4 Diabetes Mellitus. Diabetes 2000; 49: 1856-1864.
- Davydova NN, Yasuda SU, Woosley RL, and Wainer IW: Determination of clemastine in human plasma by gas chromatography with nitrogen-phosphorous detection. J Chromatogr B 2000; 744: 177-182.
- Di Marco MP, Wainer IW, Granvil CL, Batist G, and Ducharme MP: New insights into the pharmacokinetics and metabolism of (R,S)-ifosfamide in cancer patients using a population pharmacokinetics model. Pharm Res 2000; 17: 645-652.
- Gowdak LHW, Poliakova L, Wang X, Kovesdi I, Fishbein KW, Zacheo A, Palumbo R, Starino S, Emanueli C, Marrocco-Trischitta M, Lakatta EG, Anversa P, Spencer RGS, Talan M, and Capogrossi MC: Adenovirus-mediated VEGF121 gene transfer stimulates angiogenesis in normoperfused skeletal muscle and preserves tissue perfusion after induction of ischemia. Circulation 2000; 102: 565-571.
- Harms GS, Cognet L, Lommerse PH, Blab GA, Kahr H, Gamsjaeger R, Spaink HP, Soldatov NM, Romanin C, and Schmidt T: Single-molecule imaging of L-type Ca2+ channels in live cells. Biophys J 2000; 81: 2639-2646.
- Horsk� A, Fishbein KW, Fleg JL, and Spencer RGS: The relationship between creatine kinase reaction kinetics and exercise intensity in human forearm is unchanged by age. Am J Physiol 2000; 279 (Endocrinology and Metabolism): E333-E339.
- Kepplinger KJF, F�rstner G, Kahr H, Leitner K, Groschner K, Soldatov NM, and Romanin C: Molecular determinant for run-down of L-type Ca2+ channels localized in the carboxylterminus of the a1C subunit. J Physiol 2000; 529: 119-130.
- Kepplinger KJF, Kahr H, F�rstner G, Sonnleitner M, Schneider H, Schmidt T, Groschner K, Soldatov NM, and Romanin C: A sequence in the carboxyl terminus of the a1C subunit critical for targeting, conductance and kinetics of L-type Ca2+ channels. FEBS Lett 2000; 477: 161-169.
- O'Neil WM, Gilfix BM, Markoglou N, Di Girolamo A, Tsoukas CM, and Wainer I.W.: Genotype and phenotype of cytochrome P450 2D6 in HIV-positive patients and patients with AIDS, Eur J Clin Pharmacol 2000; 56: 231-240.
- Perfetti R, Zhou J, Doyle ME, Egan JM: GLP-1 induces cell proliferation, PDX-1expression and increases endocrine cell mass in the pancreas of old, glucose-intolerant rats. Endocrinology 2000; 141: 4600-4605.
- Petersen EF, Fishbein KW, McFarland EW, and Spencer RGS.: 31P NMR spectroscopy ofdDeveloping cartilage produced from chick chondrocytes in a hollow-fiber bioreactor. Magn Reson Med 2000; 44: 367-372.
- Pham YT, Regina A, Farinotti R. Couraud P, Wainer IW, Roux F and Gimenez F: Interactions of racemic mefloquine and its enantiomers with P-glycoprotein in an immortalized rat brain capillary endothelial cell line, GPNT. Biochem Biophys Acta 2000; 1524: 212-219.
- Potter K, Butler J, Horton WE, and Spencer RGS: Response of engineered cartilage tissue to biochemical agents as studied by proton magnetic resonance microscopy. Arth and Rheum 2000; 43: 1580-1590.
- Romanin C, Gamsjaeger R, Kahr H, Schaufler D, Carlson O, Abernethy DR, and Soldatov NM: Ca2+ sensors of L-type Ca2+ channel. FEBS LET 2000; 487: 301-306.
- Soldatov NM, Zhenochin S, AlBanna B, Abernethy DR, Morad M: New molecular determinant for inactivation of the human L-type a1C Ca2+ channel. J Membrane Biol 2000; 177: 129-135.
- Spencer RGS and Fishbein KW: Measurement of spin-lattice relaxation times and concentrations in systems with chemical exchange using the one-pulse sequence: Breakdown of the ernst model for partial saturation in NMR spectroscopy. J Magn Reson 2000; 142: 120-135.
- Spyker DA, Harvey ED, Harvey BE, Harvey AM, Rumack BH, Peck CC, Atkinson AJ, Woosley RL, Abernethy DR, Cantilena LR: Assessment and reporting of clinical pharmacology information in drug labeling. Clin Pharmacol Ther 2000; 67: 196-200.
- Stoffers DA, Kieffer TJ, Hussain MA, Drucker DJ, Bonner-Weir S, Habener JF, Egan JM. Insulinotropic glucagon-like peptide-1 agonists stimulate expression of homeoprotein IDX-1 and increase islet mass in mouse pancreas. Diabetes 2000; 49: 741-748.
- Szayna M, Doyle ME, Betkey JA, Hollaway HW, Spencer RGS, Greig NH, Egan JM: Exendin-4 decelerates food intake, weight gain and fat deposition in Zucker rats. Endocrinology 2000; 141: 1936-1941.
- Velan SS, Spencer RGS, Zweier JL, and Kuppusamy P: Electron paramagnetic resonance oxygen mapping (EPROM): Direct visualization of oxygen concentration in tissue. Magn Reson in Med 2000; 43: 804-809.
- Wainer IW: Three-dimensional pharmacology through a 21st century mirror. Pharmaceutical News 2000; 7: 23-25.
- Williams ML, Bhargava P, Ilham C, Marshall JL, Flockhart DA, and Wainer IW: A discordance of the cytochrome P450 2C19 genotype and phenotype in patients with advanced cancer. Br J Clin Pharmacol 2000; 49: 485-488.
- Woodland C, Ito S, Granvil CP, Wainer IW, Klein J, and Koren G: Evidence of renal metabolism of ifosfamide to nephrotoxic metabolites. Life Sci 2000; 68: 109-117.
- Zhang Y, Leonessa F, Clarke R, and Wainer IW: Development of an immobilized P-glycoprotein stationary phase for on-line liquid chromatographic determination of drug-binding affinities. J Chromatogr B 2000; 739: 33-37.
- Abernethy DR, Schwartz JB: Calcium antagonist drugs. N Engl J Med 1999; 341: 1447-1457.
- Bernstein ML, Baruchel S, Devine S, Markoglou N, Wainer IW, Williams M, Blaney S, Moghrabi A, Winick N, and Vietti T: A phase-1 and pharmacokinetic study of CI980 in recurrent pediatric solid tumor cases: A pediatric oncology group study. J Pediatr Hematol Oncol 1999; 21: 494-500
- Brandsteterova E, and Wainer IW: Achiral and chiral high-performance liquid chromatography of verapamil and its metabolites in serum samples. J Chromatogr B 1999; 732: 395-404.
- Brandsteterova E, Wainer IW and Tracy T: Achiral and chiral HPLC analysis of norverapamil and its metabolites in microsomal samples. Neoplasma 1999; 46: 207-211.
- Choudhary G, Chakel J, Hancock W, Torres-Duarte A., McMahon G, Wainer IW: Investigation of the potential of capillary electrophoresis (CE) with off-line matrix assisted laser desorption/ionization time of flight (MALDIOF) mass spectrometry for clinical analysis:examination of a glycoprotein factor associated with cancer cachexia. Anal Chem 1999; 71: 855-859.
- Choudhary G, Hancock W, Witt K, Rozing G, Torres-Duarte A, and Wainer IW: Integrated approach to the multidimensional analysis of complex biological samples by microseparation techniques. Analysis of glycoprotein factor associated with cancer cachexia. J Chromatogr A 1999; 857: 183-192.
- Curiel R, Garcia CS, Rottshafer S, Bosco MC, and Espinoza-Delgado I: Enhanced B7-2 gene expression by interferon-gamma in human monocytic cells is controlled through transcriptional and posttranscriptional mechanisms. Blood 1999; 94: 1782.
- Dassaing C, Gonin J, Wilcox CS, and Wainer IW: Determination of reduced and oxidized homocysteine and related thiols in plasma by thiol-specific pre-column derivatization and capillary electrophoresis with laser-induced fluorescence detection. J Chromatogr B 1999; 735: 219-227.
- Davydova NN, Gotti R, Welch WJ, Wainer IW: Determination of iothalamate in rat urine, Plasma and tubular fluid by capillary electrophoresis. J.Chromatogr B 1999; 728: 143-149.
- Donahue S, Flockhart DA, Abernethy DR: Ticlopidine inhibits phenytoin clearance. Clin Pharmacol Ther 1999; 66: 563-568.
- Espinoza-Delgado I: Cancer Vaccines. The Oncologist 1999; 7(Suppl 3): 20-33.
- Gourmel B, Granvil CP, Denis SL, Wainer IW, and Bousquet B: Determination of 4-hydroxyifosfamide concomitantly with ifosfamide and its dechloroethylated metabolites using gas chromatography and a nitrogen phosphorous-selective detector. J Chromatogr B 1999; 732: 3-15.
- Granvil CP, Madan A, Sharkawi M, Parkinson A, Wainer IW: Role of CYP2B6 and CYP3A4 in the in vitro N-dechloroethylation of (R)- and (S)-ifosfamide in human liver microsomes. Drug Metab Dispos 1999; 27: 533-541.
- Horsk� A, Brant LJ, Ingram DK, Hansford RG, Roth GS, and Spencer RGS: Effect of long term caloric restriction and free exercise on peripheral muscle bioenergetics and force development in the rat. Am J Physiol 1999; 276: E766-E773.
- Jones DS, Andrawis NS, Abernethy DR: Impaired endothelial-dependent forearm vascular relaxation in black Americans. Clin Pharmacol Ther 1999; 65: 408-412.
- Kimko HC, Cross JT, Abernethy DR: Pharmacokinetics and clinical effectiveness of methylphenidate. Clin Pharmacokinet 1999; 37: 457-470.
- Krecic-Shepard ME, Barnas CR, Slimko J, Gorski JC, Wainer IW, and Schwartz JB: In vivo comparison of putative probes of CYP3A4/5 activity: Erythromycin, extromethorphanandverapamil. Clin Pharmacol Ther 1999; 66: 40-50.
- Mouro C, Bondon A, Jung C, Hui Bon Hoa G, De Certaines JD, Spencer RGS, and Simonneaux G: Proton nuclear magnetic resonance study of the binary complex of cytochrome P450cam and putidaredoxin: Interaction and electron transfer rate analysis. FEBS Letters 1999; 455: 302-306.
- O'Neil WM, Pezzullo JC, Di Girolamo A, Tsoukas CM, and Wainer IW: Glucuronidation and sulphation of paracetamol in HIV positive patients with patients with AIDS. Br J Clin Pharmacol 1999; 48: 811-818.
- Rodriguez I, Abernethy DR, Woosley RL: P-glycoprotein in clinical cardiology. Circulation 1999; 99: 472-474.
- Schulman KA, Abernethy DR, Rathore SS, Woosley RL: Regulatory evidence based medicine. Clin Pharmacol Ther 1999; 66: 593-597.
- Spencer RGS: (Editor) Advanced signal processing in magnetic resonance imaging, Part 1. Int & J Imaging Syst Tech 1999; 10(2): 107-108.
- Spencer RGS: (Editor) Advanced signal processing in magnetic resonance imaging, Part 2. Int & J Imaging Syst Tech 1999; 10(3): 207-208.
- Tracy TS, Korzekwa KR, Gonzalez FJ, Wainer IW: Cytochrome P450 isoforms involved in metabolism of the enantiomers of Verapamil and Norverapamil. Br J Clin Phamacol 1999;47: 545-552.
- Vila Petroff MG, Younes A, Egan JM, Lakatta EG, Sollott SJ: Activation of distinct cAMP and cGMP-dependent pathways by nitric oxide. Circ Res 1999; 84: 1020-1031.
- Wainer IW, Zhang Y, Xiao Y, Kellar KJ: Liquid chromatographic studies with an immobilized neuronal nicotinic acetylcholine receptor stationary phases: Effects of receptor subtypes, pH and ionic strength on drug-receptor interactions. J Chromatogr B 1999; 724: 65-72.
- Wang H, Lee-Kwon W, Martindale JL, Adams L, Heller P, Egan JM, Bernier M: Modulation of CCAAT/EBP alpha gene expression by metabolic signals in rodent adipocytes. Endocrinology 1999; 140: 2938-2947.
- Wang X, Cahill CM, Pineyro MA, Zhou J, Doyle ME, Egan JM: Glucagon-like peptide-1 regulates the beta cell transcription factor, PDX-1, in insulinoma cells. Endocrinology 1999; 140: 4904-4907.
- Williams ML, and Wainer IW: Cyclophosphamide versus ifosfamide: "To use ifosfamide or not to use, that is the three-dimensional question". Current Pharmaceut Design 1999; 5: 665-672.
- Williams ML, Wainer IW, Embree L, Granvil CP, Ducharme MP: Enantioselective induction of cyclophosphamide metabolism by phenytoin. Chirality 1999; 11: 569-574.
- Williams ML, Wainer IW, Granvil CP, Gehrcke B, Bernstein ML, and Ducharme MP: Pharmacokinetics of (R)- and (S)-cyclophosphamide and their dechloroethylated metabolites in cancer patients. Chirality 1999; 11: 301-308.
- Yang H, Egan JM, Rodgers BD, Bernier M, Montrose-Rafizadeh C: Differential expression of a novel seven transmembrane protein in epididymal fat of aged and diabetic mice. Endocrinology 1999; 140: 2859-2867.
- Zhang W, Parentau H, Greenly RL, Metz CA, Aggarwal S, Wainer IW, and Tracy TS: Effect of protein-calorie malnutrition on cytocvhromes P450 and glutathione S-transferase. Eur J Drug Metab Pharmacokinet 1999; 24: 141-147.
- Zhou J, Montrose-Rafizadeh C, Janczewski AJ, Pineyro MA, Sollott SJ, Wang Y, Egan JM: Glucagon-like peptide-1 does not mediate amylase release from AR42J cells. J.Cell Physiol 1999; 131: 470-478.
- Zhou J, Wang X, Pineyro MA, Egan JM: GLP-1 and exendin-4 convert AR42J cells into insulin- and glucagon- containing cells. Diabetes 1999; 48: 2358-2366.
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