Hepatitis, Viral, Perinatal Hepatitis B Virus
Infection Acquired in the United States or U.S. Territories
1995 Case Definition
The 1995 case definition appearing on this page was re-published incorrectly in the 1997 MMWR Recommendations and
Reports titled Case Definitions for Infectious Conditions Under Public Health Surveillance [MMWR 1997;46(RR10)]
(available at http://www.cdc.gov/mmwr/preview/mmwrhtml/00047449.htm).
Thus, the 1995 and the 1997 versions of this case definition are not identical, and the 1995 version is the correct one.
Clinical case definition
Perinatal hepatitis B in the newborn may range from
asymptomatic to fulminant hepatitis.
Laboratory criteria for diagnosis:
Case classification
HBsAg positivity in any infant aged >1-24 months
who was born in the United States or in U.S. territories to an HBsAg-positive
mother
Comment
Infants born to HBsAg-positive mothers should receive
hepatitis B immune globulin (HBIG) and the first dose of hepatitis
B vaccine within 12 hours of birth, followed by the second and third
doses of vaccine at 1 and 6 months of age, respectively. Postvaccination
testing for HBsAg and anti-HBs (antibody to HBsAg) is recommended from
3 to 6 months following completion of the vaccine series. If HBIG and
the initial dose of vaccine are delayed for >1 month after birth,
testing for HBsAg may determine if the infant is already infected.
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