Genetics of Fibromyalgia - Full Text View

Sponsored by:	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information provided by:	National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
ClinicalTrials.gov Identifier:	NCT00071162

Purpose

The Fibromyalgia Family Study identifies and collects blood samples from families with two or more members affected with Fibromyalgia Syndrome (FMS). The primary goal of the study is to identify genes that predispose people to FMS and/or symptoms related to FMS; identifying these genes may lead to a better understanding of the disease and more effective treatments.

Condition
Fibromyalgia Irritable Bowel Syndrome Chronic Fatigue Syndrome Depression

MedlinePlus related topics: Chronic Fatigue Syndrome Depression Fibromyalgia

U.S. FDA Resources

Study Type:	Observational
Study Design:	Family-Based, Retrospective
Official Title:	Fibromyalgia Family Study Registry

Further study details as provided by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS):

Biospecimen Retention: Samples With DNA

Biospecimen Description:

DNA, whole blood

Enrollment:	560
Study Start Date:	September 1999

Detailed Description:

FMS predominantly affects women and is characterized by chronic widespread musculoskeletal pain, fatigue, sleep disturbance, and multiple tender points on physical examination. The pathophysiological mechanisms underlying FMS are not clearly understood, but neuroendocrine factors seem to be of major importance. Studies of familial association suggest that genetic factors play a role in FMS. This study will establish patterns of genetic linkage in families with FMS.

Participating family members will undergo a brief physical exam (including tender point exam), donate a blood sample, and complete a detailed questionnaire that includes experience with pain, fatigue, depression, bowel symptoms, headache, anxiety, and physical limitations. Measurements of serum serotonin and related compounds will also be obtained. To detect genetic factors, a genome-wide linkage scan using 405 microsatellite markers will be performed.

Eligibility

Ages Eligible for Study:	12 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Probability Sample

Study Population

The population of this study is family based and aimed to recruit 160 multic-case FMS families. We plan to perform a genome scan and evaluate 200-300 linkage markers to FMS and FMS-related traits. Future plans include establishing a DNA and data repository for distribution for future studies.

Criteria

Inclusion Criteria

Diagnosed with fibromyalgia according to the criteria of the American College of Rheumatology
Have at least one living family member who has also been diagnosed with fibromyalgia
No other major rheumatological disease

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00071162

Locations

United States, Illinois
University of Illinois at Peoria
Peoria, Illinois, United States, 60612
United States, Ohio
Case Western Reserve University
Cleveland, Ohio, United States, 44109
University of Cincinnati
Cincinnati, Ohio, United States, 45221
United States, Texas
University of Texas Health Sciences Center
San Antonio, Texas, United States, 78229

Sponsors and Collaborators

National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Investigators

Study Chair:

Sudha Iyengar, PhD

Case Western Reserve University

More Information

Publications:

Yunus MB, Khan MA, Rawlings KK, Green JR, Olson JM, Shah S. Genetic linkage analysis of multicase families with fibromyalgia syndrome. J Rheumatol. 1999 Feb;26(2):408-12.

Responsible Party:	Case Western Reserve University ( Sudha Iyengar, PhD )
Study ID Numbers:	NIAMS-100
Study First Received:	October 14, 2003
Last Updated:	September 3, 2008
ClinicalTrials.gov Identifier:	NCT00071162
Health Authority:	United States: Federal Government

Keywords provided by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS):

Pain
Fatigue
Sleep

Depression
Irritable Bowel Syndrome
Chronic Fatigue Syndrome

Study placed in the following topic categories:

Gastrointestinal Diseases
Colonic Diseases
Pain
Encephalomyelitis
Fatigue Syndrome, Chronic
Signs and Symptoms
Musculoskeletal Diseases
Neuromuscular Diseases
Mental Disorders
Irritable Bowel Syndrome
Depression
Fatigue
Myofascial Pain Syndromes

Fibromyalgia
Myalgic encephalomyelitis
Central Nervous System Diseases
Rheumatic Diseases
Depressive Disorder
Intestinal Diseases
Behavioral Symptoms
Virus Diseases
Muscular Diseases
Digestive System Diseases
Mood Disorders
Colonic Diseases, Functional

Additional relevant MeSH terms:

Pathologic Processes
Disease
Syndrome
Nervous System Diseases

ClinicalTrials.gov processed this record on January 16, 2009