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Clinical Trials by Cancer Site

Leukemia

Leukemia is a disease that affects both children and adults, but it is most prevalent in adults. Males are more likely to be diagnosed with leukemia than females. The major types and most commonly diagnosed leukemias are: Acute Myelogenous Leukemia (AML), Acute Lymphocytic Leukemia (ALL), Chronic Myelogenous Leukemia (CML), and Chronic Lymphocytic Leukemia (CLL). ALL is the most frequently diagnosed type of leukemia among children between the ages of 0 and 19. In adults, the most commonly diagnosed types of leukemia are AML and CLL. Risk factors associated with leukemia include genetic abnormalities, cigarette smoking, exposure to certain chemicals (e.g., Benzene), and ionizing radiation. Leukemia may also occur as a side effect of cancer treatment.

Treatment options may vary depending on the type of leukemia, stage of the disease, patient's age, and other medical conditions, and should be discussed with the patient's physician.

Leukemia Clinical Trials

The Center for Cancer Research (CCR), NCI's largest division doing research on campus, conducts leukemia clinical trials at the NIH Clinical Center in Bethesda, Md. NCI accepts referrals to leukemia clinical trials conducted in Bethesda, Md., through its Clinical Trials Referral Office (formerly called the Clinical Studies Support Center) at 1-888-NCI-1937 (1-888-624-1937).

NCI is currently conducting the following trials for patients with leukemia. Click on the trials below for additional details, including a summary of eligibility criteria, treatment plan, and information on how to contact the principal investigators and their staff directly.


  
Trial and Protocol Number
Leukemia
Phase I/II
Phase I/II Study of the Efficacy and Toxicity of Humanized Anti-Tac (Zenapax®) in the Therapy of Tac-Expressing Adult T-Cell Leukemia
NCI-00-C-0030

Principal Investigator:Referral Contact:
John C. MorrisSuzanne Fioravanti
301-402-2912301-594-6544
fioravas@mail.nih.gov


  
Trial and Protocol Number
Leukemia (Adult)
Phase II
Phase II Trial of LMB-2, Fludarabine and Cyclophosphamide for Adult T-Cell Leukemia
NCI-09-C-0025

Principal Investigator:Referral Contact:
Robert J. KreitmanLinda Ellison
301-496-6947301-496-9458
ellisonl@mail.nih.gov
Randomized Trial of Cladribine (CdA) With Simultaneous or Delayed Rituximab to Eliminate Hairy Cell Leukemia Minimal Residual Disease
NCI-09-C-0005

Principal Investigator:Referral Contact:
Robert J. KreitmanLinda Ellison
301-496-6947301-496-9458
ellisonl@mail.nih.gov
Microarray Analysis of the Effect of Cyclosporine Therapy on Gene Expression Patterns in Large Granular Lymphocytic Leukemia
NCI-06-C-0177

Principal Investigator:Referral Contact:
John E. JanikSuzanne Fioravanti
301-402-2913301-594-6544
fioravas@mail.nih.gov
Phase II Study of LMB-2 Immunotoxin in Patients With Recurrent or Refractory CD25-Positive Hairy Cell Leukemia
NCI-06-C-0150

Principal Investigator:Referral Contact:
Robert J. KreitmanLinda Ellison
301-496-6947301-496-9458
ellisonl@mail.nih.gov
Phase II Study of the Efficacy and Toxicity of Ontak® (Denileukin Diftitox) in the Therapy of Adult T-Cell Leukemia
NCI-05-C-0185

Principal Investigator:Referral Contact:
John E. JanikSuzanne Fioravanti
301-402-2913301-594-6544
fioravas@mail.nih.gov
Phase II Study of LMB-2 Immunotoxin in Patients With CD25-Positive Chronic Lymphocytic Leukemia or Prolymphocytic Leukemia
NCI-04-C-0121

Principal Investigator:Referral Contact:
Robert J. KreitmanLinda Ellison
301-496-6947301-496-9458
ellisonl@mail.nih.gov
Phase II Trial of BL22 Immunotoxin in Hairy Cell Leukemia
NCI-04-C-0014

Principal Investigator:Referral Contact:
Robert J. KreitmanLinda Ellison
301-496-6947301-496-9458
ellisonl@mail.nih.gov
Phase II Study of the Efficacy and Toxicity of CAMPATH-1H in the Therapy of Adult T-Cell Leukemia
NCI-03-C-0194

Principal Investigator:Referral Contact:
John C. MorrisSuzanne Fioravanti
301-402-2912301-594-6544
fioravas@mail.nih.gov
Treatment of Chronic Lymphocytic Leukemia: DNA Microarray Gene Expression Analysis
NCI-97-C-0178

Principal Investigator:Referral Contact:
Wyndham H. WilsonTherese White
301-435-2415301-402-5886
whiteth@mail.nih.gov
Phase I
A Phase I, Multicenter, Dose Escalation Study of CAT-8015 in Patients With Relapsed or Refractory Hairy Cell Leukemia
NCI-07-C-0130

Principal Investigator:Referral Contact:
Robert J. KreitmanLinda Ellison
301-496-6947301-496-9458
ellisonl@mail.nih.gov
A Phase I Open-Label Single-Dose Study of Humanized MiK-Beta-1 Monoclonal Antibody Directed Toward the IL-2R/IL-15R{beta} Subunit (CD122) in T-Cell Large Granular Lymphocytic Leukemia
NCI-04-C-0089

Principal Investigator:Referral Contact:
John C. MorrisSuzanne Fioravanti
301-402-2912301-594-6544
fioravas@mail.nih.gov


  
Trial and Protocol Number
Leukemia (Childhood)
Phase I
Phase I Trial and Pharmacokinetic Study of BMS-247550 (NSC 710428, Ixabepilone), an Epothilone B Analog, in Pediatric Patients with Refractory Solid Tumors and Leukemias
NCI-02-C-0031

Principal Investigator:Referral Contact:
Brigitte WidemannPediatric Oncology
301-496-73871-877-624-4878
(Toll free)



  
Trial and Protocol Number
Graft-Versus-Host Disease
No Phase
Prospective Assessment of Clinical and Biological Factors Determining Outcomes in Patients With Chronic Graft-Versus-Host Disease (GVHD)
NCI-04-C-0281

Principal Investigator:Referral Contact:
Steven PavleticMike Krumlauf
301-402-4899301-594-2056
krumlaum@mail.nih.gov


  
Trial and Protocol Number
Hematologic/Blood Cancers
Phase II
Allogeneic HSCT Without Preparative Chemotherapy or With Low-Intensity Preparative Chemotherapy Using Sirolimus and Sirolimus Generated Donor Th2 Cells for Therapy of Refractory Leukemia, Lymphoma, Myeloma, or Myelodysplastic Syndrome
NCI-04-C-0055

Principal Investigator:Referral Contact:
Daniel FowlerMike Krumlauf
301-435-8641301-594-2056
krumlaum@mail.nih.gov
Phase I/II
A Pilot Trial of WT1 Peptide-Loaded Allogeneic Dendritic Cell Vaccine and Donor Lymphocyte Infusion for WT1-Expressing Hematologic Malignancies
NCI-08-C-0051

Principal Investigator:Referral Contact:
Alan WaynePediatric Oncology
301-496-42561-877-624-4878
(Toll free)

Pilot Trial of Targeted Immune-Depleting Chemotherapy and Reduced-Intensity Allogeneic Hematopoietic Stem Cell Transplantation Using HLA-Matched Unrelated Donors and Utilizing Two Graft-versus-Host Disease Prophylaxis Regimens for the Treatment of Leukemias, Lymphomas, and Pre-malignant Blood Disorders
NCI-07-C-0195

Principal Investigator:Referral Contact:
Michael BishopMike Krumlauf
301-435-2764301-594-2056
krumlaum@mail.nih.gov
Pilot Study of Non-Myeloablative, HLA-matched Allogeneic Stem Cell Transplantation for Pediatric Hematopoietic Malignancies
NCI-01-C-0125

Principal Investigator:Referral Contact:
Alan WaynePediatric Oncology
301-496-42561-877-624-4878
(Toll free)

Phase I
A Phase I, Multicenter, Dose Escalation Study of CAT-8015 in Children, Adolescents, and Young Adults With Refractory CD22+ Acute Lymphoblastic Leukemia (ALL) or Non-Hodgkin’s Lymphoma (NHL)
NCI-08-C-0123

Principal Investigator:Referral Contact:
Alan WaynePediatric Oncology
301-496-42561-877-624-4878
(Toll free)

Adoptive Cell Therapy for B-Cell Malignancies After Allogeneic Hematopoietic Stem Cell Transplantation With Costimulated, Tumor-Derived Lymphocytes
NCI-07-C-0064

Principal Investigator:Referral Contact:
Michael BishopMike Krumlauf
301-435-2764301-594-2056
krumlaum@mail.nih.gov
Multi-Institutional Phase I Trial of Intravenous Fenretinide (4-HPR) for Patients With Hematologic Malignancies
NCI-06-C-0227

Principal Investigator:Referral Contact:
Anthony J. MurgoJanelle Bingham
301-496-4291301-435-2715
jbingham@mail.nih.gov
T-Cell Depleted, Reduced-Intensity Allogeneic Stem Cell Transplantation From Haploidentical Related Donors for Hematologic Malignancies
NCI-04-C-0116

Principal Investigator:Referral Contact:
Michael BishopMike Krumlauf
301-435-2764301-594-2056
krumlaum@mail.nih.gov
Pediatric Phase I Trial of BL22 for Refractory CD22-Positive Leukemias and Lymphomas
NCI-04-C-0079

Principal Investigator:Referral Contact:
Alan WaynePediatric Oncology
301-496-42561-877-624-4878
(Toll free)



  
Trial and Protocol Number
Pediatric Cancers
Phase I
A Phase I Study of the Raf Kinase and Receptor Tyrosine Kinase Inhibitor BAY 43-9006 (Sorafenib) in Children With Refractory Solid Tumors or Refractory Leukemias
NCI-06-C-0233

Principal Investigator:Referral Contact:
Brigitte WidemannPediatric Oncology
301-496-73871-877-624-4878
(Toll free)

Phase I Trial of Cediranib (AZ2171), an Orally Bioavailable Antiangiogenic Agent, in Children and Adolescents With Refractory or Recurrent Solid Tumors or Acute Myelogenous Leukemia
NCI-06-C-0152

Principal Investigator:Referral Contact:
Elizabeth FoxPediatric Oncology
301-402-66411-877-624-4878
(Toll free)



  
Trial and Protocol Number
Solid Tumor (Adult)
Phase I
Phase I Study of SNX-5422 Mesylate in Adults With Refractory Solid Tumor Malignancies and Lymphomas
NCI-08-C-0091

Principal Investigator:Referral Contact:
Giuseppe GiacconeJanelle Bingham
301-496-4916301-435-2715
jbingham@mail.nih.gov


  
Trial and Protocol Number
Solid Tumor (Childhood)
Phase I
A Phase I Study of BMS-354825 (Dasatinib) in Children With Recurrent/Refractory Solid Tumors or Imatinib Resistant Ph+ Leukemia (A Cooperative Group Study)
NCI-07-C-0166

Principal Investigator:Referral Contact:
Elizabeth FoxPediatric Oncology
301-402-66411-877-624-4878
(Toll free)



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