Anger Control Training for Youth With Tourette Syndrome - Full Text View

Sponsors and Collaborators:	Yale University National Institute of Mental Health (NIMH) Tourette Syndrome Association
Information provided by:	Yale University
ClinicalTrials.gov Identifier:	NCT00486551

Purpose

This is a clinical study of a cognitive-behavioral therapy known as anger control training in adolescents with Tourette Syndrome and explosive, disruptive behavior. ACT is compared to treatment as usual (TAU) in a randomized clinical trial.

Condition	Intervention
Tourette Syndrome Chronic Tic Disorder Oppositional Defiant Disorder ADHD	Behavioral: Anger control training

Genetics Home Reference related topics: familial encephalopathy with neuroserpin inclusion bodies familial paroxysmal nonkinesigenic dyskinesia Tourette syndrome

MedlinePlus related topics: Tourette Syndrome

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Single Blind, Active Control, Parallel Assignment, Efficacy Study
Official Title:	Anger Control Training for Youth With Tourette Syndrome

Further study details as provided by Yale University:

Primary Outcome Measures:

CGI-I assigned by clinician unaware of treatment assignment [ Time Frame: three months ]
Parent rated disruptive behavior [ Time Frame: three months ]

Enrollment:	26
Study Start Date:	August 2001
Study Completion Date:	January 2006

Detailed Description:

This is a randomized controlled study of a cognitive-behavioral, anger control training (ACT) in adolescents with Tourette Syndrome (TS) complicated by disruptive behavior. Disruptive behaviors in TS may take numerous forms including noncompliance, anger outbursts, and physical aggression. Anger outbursts in TS have been described as rage attacks or rage storms due to their high intensity and unpredictability in response to minimal provocation. Whether these behaviors are part of TS, related to comorbid conditions, or due to the burden of chronic illness is not clear. Nevertheless, these disruptive behaviors can result in significant functional impairment and often require clinical attention. The purpose of the ACT intervention is to improve the explosive and noncompliant behavior in adolescents with TS by enhancing affect regulation and social problem-solving skills. The treatment is based on anger control training which has been empirically supported for reducing aggressive behaviors and improving social functioning in aggressive youths. The primary outcome measures include the parent-rated Oppositional Defiant Scale and the Clinicians Global Improvement Score assessed by a clinician blind to treatment assignment.

Eligibility

Ages Eligible for Study:	11 Years to 16 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

Boys and girls, 11 to 16 years of age.
Diagnosis of Tourette syndrome (TS) or chronic tic disorder (CTD).
Significant level of disruptive behavior

Exclusion Criteria:

Current diagnosis of Severe Major Depression, Bipolar Disorder, Pervasive Developmental Disorder, or Psychotic Disorder.
Significant medical condition such as heart disease, hypertension, liver or renal failure, pulmonary disease, seizure disorder that may require more pressing treatment.
Initiation or discontinuation of a psychotropic medication treatment within six weeks of enrollment in the study

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00486551

Locations

United States, Connecticut
Yale University School of Medicine, Child Study Center
New Haven, Connecticut, United States, 06520

Sponsors and Collaborators

Yale University

National Institute of Mental Health (NIMH)

Tourette Syndrome Association

Investigators

Principal Investigator:	Denis G Sukhodolsky, Ph.D.	Yale University
Principal Investigator:	Lawrence D Scahill, Ph.D.	Yale University

More Information

Related Info This link exits the ClinicalTrials.gov site

Publications:

Sukhodolsky DG, Scahill L, Zhang H, Peterson BS, King RA, Lombroso PJ, Katsovich L, Findley D, Leckman JF. Disruptive behavior in children with Tourette's syndrome: association with ADHD comorbidity, tic severity, and functional impairment. J Am Acad Child Adolesc Psychiatry. 2003 Jan;42(1):98-105.

Sukhodolsky DG, do Rosario-Campos MC, Scahill L, Katsovich L, Pauls DL, Peterson BS, King RA, Lombroso PJ, Findley DB, Leckman JF. Adaptive, emotional, and family functioning of children with obsessive-compulsive disorder and comorbid attention deficit hyperactivity disorder. Am J Psychiatry. 2005 Jun;162(6):1125-32.

Scahill L, Erenberg G, Berlin CM Jr, Budman C, Coffey BJ, Jankovic J, Kiessling L, King RA, Kurlan R, Lang A, Mink J, Murphy T, Zinner S, Walkup J; Tourette Syndrome Association Medical Advisory Board: Practice Committee. Contemporary assessment and pharmacotherapy of Tourette syndrome. NeuroRx. 2006 Apr;3(2):192-206. Review.

Study ID Numbers:	1R03MH67845
Study First Received:	June 12, 2007
Last Updated:	June 13, 2007
ClinicalTrials.gov Identifier:	NCT00486551
Health Authority:	United States: Institutional Review Board

Keywords provided by Yale University:

Anger control training
Cognitive behavioral therapy
Behavior therapy
Tourette Syndrome

Randomized trial
Anger
Aggression

Study placed in the following topic categories:

Ganglion Cysts
Basal Ganglia Diseases
Attention Deficit and Disruptive Behavior Disorders
Central Nervous System Diseases
Tourette Syndrome
Tic Disorders
Neurodegenerative Diseases
Brain Diseases
Dyskinesias
Tics

Signs and Symptoms
Oppositional defiant disorder
Heredodegenerative Disorders, Nervous System
Genetic Diseases, Inborn
Mental Disorders
Movement Disorders
Mental Disorders Diagnosed in Childhood
Neurologic Manifestations
Gilles de la Tourette's syndrome
Aggression

Additional relevant MeSH terms:

Pathologic Processes
Disease
Syndrome
Nervous System Diseases

ClinicalTrials.gov processed this record on January 16, 2009