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Sponsored by: |
National Institute of Neurological Disorders and Stroke (NINDS) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00056420 |
This study will use electroencephalography (EEG) and electromyography (EMG) to examine how the brain generates tics and controls voluntary movement in patients with Tourette's syndrome and chronic motor tic disorder. EEG records the electrical activity of the brain. For this test, a cap with built-in electrodes is placed on the subject's head, and the electrodes are connected to a monitor that records the brain activity. EMG records muscle activity using electrodes placed on the skin over muscles on the fingers or above the outer corner of the eyes.
Healthy normal volunteers and patients with Tourette's syndrome and chronic motor tic disorder between 21 and 65 years of age may be eligible for this 2- to 3-hour study. Each candidate will be screened with a medical history, physical and neurological examinations, and a questionnaire that screens for psychiatric disorders.
During EEG and EMG recordings, participants undergo the following tasks while seated comfortably in a sound-shielded room:
Patients
Normal Volunteers
Condition |
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Tourette Syndrome Tic Disorders |
Study Type: | Observational |
Official Title: | Spatiotemporal Dynamics of Cortical Connectivity Involved in Tics and Voluntary Movements in Patients With Tourette's Syndrome and Chronic Motor Tic Disorder: An EEG Study |
Estimated Enrollment: | 54 |
Study Start Date: | March 2003 |
This study examines the spatiotemporal dynamics of cortical functional interconnectivity involved tics and voluntary movement in patients with Tourette's syndrome or chronic motor tic disorder. By employing a combination of EEG methods that utilize analyses in the domains of both frequency (e.g., event-related desynchronization/synchronization (ERD/ERS), event-related partial coherence, phase coherence) and time (e.g., event-related partial correlation), we intend to determine
Ages Eligible for Study: | 21 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
HEALTHY VOLUNTEERS:
Healthy volunteers are between the ages of 21 and 65 years.
PATIENTS:
Patients will have clinically documented Tourette's syndrome or chronic motor tic disorder as defined by DSM-IV-TR and evaluation of tic severity using the Yale Tic Scale. This criterion will be established by preliminary screening in the NINDS Movement Disorders Outpatient Clinic. Regarding co-morbid disorders such as ADHD and OCD, we will accept a mild degree of ADHD and mild to moderate degree of OCD. These disorders will be established by a psychiatrist using below listed scales and criteria.
Structure Clinical Interview for (DSMIV SCID) will be administered to all subjects to ensure that strict DSM-IV criteria for Tourette Syndrome have been met and to assess for possible comorbid psychiatric disorders.
Given the high rate of comorbidity of Obsessive Compulsive Disorder (OCD) and Attention Deficit/Hyperactivity Disorder (ADHD) in Tourette's syndrome, it may not be possible to exclude persons with these disorders. Hence, only those with no more than mild to moderate severity of symptoms will be accepted into the study. This will be ascertained using the following instruments and their respective cut-off scores:
Y-BOCS (Goodman et al, 1989) a 10 item scale with a range of 0 - 4 and maximum possible score of 40 (0-7: subclinical; 8 - 15: mild; 16 -23: moderate; 24 - 31 severe; 32 - 40: extreme). Inclusion criteria: 23 or below.
ADHD Behavior Checklist for Adults (Barkley, 1995, Murphy and Barkley, 1995): An 18 Item checklist with 9 Inattention items and 9 Hyperactive/impulsive items ranging 0 - 3 (0: never or rarely 1: sometimes 2: often and 3: very often ). Items answered often or very often are scored as present. With age, the threshold criterion for presence of ADHD become lower and is currently accepted as follows:
Age Range; Inattention Items; Hyperactive and Impulsive Items respectively:
21-29 years; 4 of 9; 5 of 9
30-49; 4 of 9; 4 of 9
50 and over; 3 of 9; 3 of 9
Inclusion Criteria:
Age Range; Inattention Items; Hyperactive and Impulsive Items respectively:
21-29 years; 3 or below; 4 or below
30-49; 3 or below; 3 or below
50 and over; 2 or below; 2 or below
EXCLUSION CRITERIA IN HEALTHY VOLUNTEERS AND PATIENTS:
The following subjects will be excluded from the study:
Contact: Patient Recruitment and Public Liaison Office | (800) 411-1222 | prpl@mail.cc.nih.gov |
Contact: TTY | 1-866-411-1010 |
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
Bethesda, Maryland, United States, 20892 |
Study ID Numbers: | 030126, 03-N-0126 |
Study First Received: | March 12, 2003 |
Last Updated: | July 18, 2008 |
ClinicalTrials.gov Identifier: | NCT00056420 |
Health Authority: | United States: Federal Government |
Tourette's Syndrome Tic Disorder (EEG) Electroencephalography Event-Related Desynchronization/Synchronization Coherence |
Tourette's Tourette Syndrome Tic Disorder Healthy Volunteer HV |
Ganglion Cysts Basal Ganglia Diseases Central Nervous System Diseases Tourette Syndrome Healthy Tic Disorders Neurodegenerative Diseases Brain Diseases Dyskinesias |
Tics Signs and Symptoms Heredodegenerative Disorders, Nervous System Genetic Diseases, Inborn Movement Disorders Mental Disorders Mental Disorders Diagnosed in Childhood Neurologic Manifestations Gilles de la Tourette's syndrome |
Pathologic Processes Disease Syndrome Nervous System Diseases |