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Sponsored by: |
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) |
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Information provided by: | National Institutes of Health Clinical Center (CC) |
ClinicalTrials.gov Identifier: | NCT00001265 |
This study of inflammatory muscle diseases-polymyositis and dermatomyositis and related disorders-will examine what causes these diseases and describe the clinical features (signs and symptoms) associated with them. Inflammation and degeneration of skeletal muscles in these disorders leads to weakness and muscle wasting. The skin, lungs and other organs may also be involved.
Patients 16 years of age and older with polymyositis, dermatomyositis, or a related disorder may be eligible for this study. Participants will undergo a complete history and physical examination, including routine blood and urine tests. Additional procedures for diagnosis, treatment or research may include:
Patients who are eligible for experimental treatment studies will be offered the opportunity to join them. Others will be advised of treatment recommendations.
Condition |
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Autoimmune Disease Dermatomyositis Inclusion Body Myositis Myositis Polymyositis |
Study Type: | Observational |
Official Title: | Studies on the Natural History and Pathogenesis of Polymyositis, Dermatomyositis, and Related Diseases |
Study Start Date: | August 1991 |
Polymyositis, dermatomyositis and related disorders, also known as the idiopathic inflammatory myopathies (IIM), are an uncommon, heterogenous group of diseases. This is an omnibus protocol designed to continue our description of this rare group of diseases, further delineate important groups of patients, and obtain useful material for further study on the immunological abnormalities, pathogenesis and etiology of IIM. Often the diagnosis of an IIM can be confused with other illness (such as adult-onset dystrophies), and therefore, we will be evaluating patients with other illnesses (who are referred with a preliminary diagnosis of an IIM). Patients evaluated with IIM will receive with informed consent the best standard therapies available and consideration for entry into any therapeutic protocols. MRI will be performed on healthy volunteers to help develop a mathematical method for quantitating edema of muscle MRI in patients.
Ages Eligible for Study: | 16 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Patients with known or suspected idiopathic inflammatory myopathies (IIM) or patients with other connective tissue diseases with weakness or myalgias for an inflammatory myopathy or other muscle process.
EXCLUSION:
None other than inclusion criteria.
Contact: Patient Recruitment and Public Liaison Office | (800) 411-1222 | prpl@mail.cc.nih.gov |
Contact: TTY | 1-866-411-1010 |
United States, Maryland | |
National Institutes of Health Clinical Center, 9000 Rockville Pike | Recruiting |
Bethesda, Maryland, United States, 20892 | |
United States, Oklahoma | |
Oklahoma Medical Research Foundation | Recruiting |
Oklahoma City, Oklahoma, United States, 73104 |
Study ID Numbers: | 910196, 91-AR-0196 |
Study First Received: | November 3, 1999 |
Last Updated: | August 19, 2008 |
ClinicalTrials.gov Identifier: | NCT00001265 |
Health Authority: | United States: Federal Government |
Autoimmune Diseases Idiopathic Inflammatory Myopathies Polymyositis Dermatomyositis |
Inclusion Body Myositis Pathogenesis Connective Tissue Diseases |
Myositis Dermatomyositis Autoimmune Diseases Muscular Diseases Skin Diseases Neuromuscular Diseases |
Musculoskeletal Diseases Myositis, inclusion body Connective Tissue Diseases Polymyositis Idiopathic myopathy Myositis, Inclusion Body |
Immune System Diseases Nervous System Diseases |