Inclusion Criteria:

• Male or female
• Age 18/19 (dependent on local age of majority) - 55 years
• Body mass index of 19 - 29
• For female subjects that are not surgically sterilized, willingness to use an effective method of contraception throughout the trial including:
• Using hormonal contraception (oral, injectable or implant) continuously for 3 months prior to the start of the trial and willing to continue to use hormonal contraception throughout the entire trial.
• IUD inserted at least 3 months prior to dosing.
• For female subjects who are postmenopausal < 2 years an FSH ≥ 40 mIU/mL must be obtained. If the FSH is < 40 mIU/mL the subject must agree to use an acceptable form of contraception (see above).
• For males that have not had a vasectomy, willingness to use a condom with spermicide for the duration of the study. Also, male subjects must not donate sperm for the duration of the study.
• Normal and healthy as determined by medical history, physical exam, ECG, vital signs and laboratory tests of liver, kidney and hematological functions
• Written informed consent

Exclusion Criteria:

• Heavy smokers (>10 cigarettes/day) or individuals using smokeless tobacco or nicotine containing products
• Use of any investigational product within the past 30 days
• Recipient of any blood product within the past 12 months
• Plasma donation within 7 days or significant blood loss or blood donation within 56 days of baseline
• Females with a hemoglobin level < 12 g/dL
• Males with a hemoglobin level < 13 g/dL
• History of hypersensitivity to blood products
• History of allergy to latex or rubber
• History of IgA deficiency
• Pregnancy or lactation
• Positive serology test for HIV or HCV, positive test for HBV as determined by HBsAg.
• History of, or suspected substance abuse problem (including alcohol)
• Failure of drug test at screening or baseline
• Failure of alcohol test at baseline or consumption of alcoholic beverages within 48 hours of baseline
• History of anthrax vaccination with AVA or any other anthrax vaccine
• Individuals with planned medical procedures that will occur during the study
• Use of prescription medications within 7 days prior to baseline, or anticipated use during the study (with the exception of hormonal contraceptives for females)
• Use of over-the-counter, herbal medications or vitamins within 7 days of study admission
• An opinion of the investigator that it would be unwise to allow participation of the subject in the study