Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone

This study is enrolling participants by invitation only.

Sponsored by:	State University of New York - Upstate Medical University
Information provided by:	State University of New York - Upstate Medical University
ClinicalTrials.gov Identifier:	NCT00615628

Purpose

Researchers have previously demonstrated loss of heterozygosity in a region on chromosome 18q, associated with osteogenic sarcomas in bone affected by Paget's disease. The loci used in this study are specifically described by those authors as showing loss of heterozygosity in 6 of 7 affected families.

Condition
Osteosarcoma Paget's Disease

MedlinePlus related topics: Bone Diseases Paget's Disease of Bone

U.S. FDA Resources

Study Type:	Observational
Study Design:	Family-Based, Prospective
Official Title:	Inheritance of Osteosarcoma & Paget's Disease Through Chromosome 18: Examination of Osteosarcoma Tissue Samples From Two Family Members for Loss of Heterozygosity in the Chromosome 18 Region, Genetically Linked With Paget's Disease of Bone

Further study details as provided by State University of New York - Upstate Medical University:

Biospecimen Retention: Samples With DNA

Biospecimen Description:

Once a specimen is obtained DNA will be isolated for paraffin-embedded tissue and peripheral blood. Osteosarcoma samples from paraffin embedded, formalin-fixed post-surgical tissue samples will be obtained for the proband and father. Matched normal spamples will be obtained from these individuals as adjacent normal tissue from the post-surgical specimens

Estimated Enrollment:	9
Study Start Date:	April 2002
Estimated Primary Completion Date:	April 2009 (Final data collection date for primary outcome measure)

Groups/Cohorts
1

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No
Sampling Method:	Non-Probability Sample

Study Population

This is a familial study therefore the only inclusion/exclusion criteria would be that subjects must be a blood relative and over the age of 18. The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son.

Criteria

Inclusion Criteria:

This is a familial study therefore the only inclusion/exclusion criteria would be that subjects must be a blood relative and over the age of 18.
The subjects are proband and father along with unaffected blood relatives. Their peripheral blood will act as a control and provide information to delineate the inheritance from the father, as seen in the son.

Exclusion Criteria:

Not part of the family

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00615628

Locations

United States, New York
SUNY Upstate Medical University
Syracuse, New York, United States, 13202

Sponsors and Collaborators

State University of New York - Upstate Medical University

Investigators

Principal Investigator:

Timothy A Damron, MD

State University of New York - Upstate Medical University

More Information

Responsible Party:	Orthopedic Surgery ( Timothy A Damron, MD )
Study ID Numbers:	Osteosarcoma & Paget's Disease, IRB #4168
Study First Received:	February 1, 2008
Last Updated:	December 1, 2008
ClinicalTrials.gov Identifier:	NCT00615628
Health Authority:	United States: Institutional Review Board

Keywords provided by State University of New York - Upstate Medical University:

Inheritance of Osteosarcoma & Paget's Disease through Chromosome 18

Study placed in the following topic categories:

Neoplasms, Connective and Soft Tissue
Musculoskeletal Diseases
Malignant mesenchymal tumor
Osteitis Deformans
Sarcoma
Osteosarcoma

Osteogenic sarcoma
Osteitis
Bone Diseases
Soft tissue sarcomas
Pagets disease

Additional relevant MeSH terms:

Neoplasms
Neoplasms by Histologic Type
Neoplasms, Bone Tissue
Neoplasms, Connective Tissue

ClinicalTrials.gov processed this record on January 16, 2009