Technology for Structural Biology - National Center for Research Resources

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Research Resources
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Twelve Biomedical Technology Research Centers (BTRCs) are supported in the broad area of Structural Biology to develop technologies for studying the structures of biomolecules in the size range of peptides to cells using nuclear magnetic resonance (NMR), synchrotron radiation and multiple types of microscopy. A combined goal of Structural Biology and Systems Biology areas is to understand the functions and mechanisms of important biological molecules in their various forms and in the different places they show up in the cell throughout the cell cycle.

The National Center for Research Resources and the National Institute of General Medical Sciences convened a working group on April 27–28, 2008, to advise us on the capabilities of and capacity needed for life sciences research at the National Synchrotron Light Source-II (NSLS-II). NSLS-II is a new Department of Energy synchrotron facility to be built over the next several years, replacing the current NSLS, and is scheduled to become fully operational in 2015. The panel has issued a report. READ MORE >>

Research Resource

•	BioCARS: A Synchrotron Structural Biology Resource synchrotron center for macromolecular crystallography	Principal Investigator Keith Moffat, Ph.D.
•	Biophysics Collaborative Access Team x-ray scattering usign synchrotron radiation to study macromolecular structure	Principal Investigator Thomas Irving, Ph.D.
•	Macromolecular Crystallography at the National Synchrotron Light Source synchrotron center for macromolecular crystallography	Principal Investigator Robert M. Sweet, Ph.D.
•	Macromolecular Diffraction Biotechnology Resource synchrotron center for macromolecular crystallography	Principal Investigator Richard A. Cerione, Ph.D.
•	National Biomedical Center for Advanced ESR Technology electron spin resonance technology	Principal Investigator Jack H. Freed, Ph.D.
•	National Magnetic Resonance Facility at Madison nuclear magnetic resonance spectroscopy	Principal Investigator John L. Markley, Ph.D.
•	National Resource for Automated Molecular Microscopy electron microscopy at the molecular level	Principal Investigator Bridget Carragher
•	Synchrotron Radiation Structural Biology Resource synchrotron center for macromolecular crystallography	Principal Investigator Keith O. Hodgson, Ph.D.
•	Three-Dimensional Electron Microscopy of Macromolecules CryoEM at subnanometer resolution	Principal Investigator Wah Chiu, Ph.D.
•	Three-Dimensional Fine Structure of Cells and Tissues electron microscopy at the cellular level	Principal Investigator Andreas Hoenger, Ph.D.
•	Undulator Resource for Structural Biology synchrotron center for macromolecular crystallography	Principal Investigator Steven E. Ealick, Ph.D.
•	Visualization of Biological Complexity Resource electron microscopy at the molecular level	Principal Investigator Joachim Frank, Ph.D.

Contact Information

For further information about NCRR support for Technology for Structural Biology resources, contact:

Amy L. Swain, Ph.D.
Division of Biomedical Technology
National Center for Research Resources
National Institutes of Health
One Democracy Plaza, Room 962
6701 Democracy Boulevard, MSC 4874
Bethesda, Maryland 20892-4874 (20817 for express mail)
Telephone: 301-435-0755
Fax: 301-480-3659
E-mail: SwainA@mail.nih.gov