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This page contains brief information about cyclophosphamide and a collection of links to more information from the National Cancer Institute (NCI), the Food and Drug Administration (FDA), and the National Library of Medicine (NLM).

US Brand Name(s):		Clafen
		Cytoxan
		Neosar
FDA Approved:		Yes

Cyclophosphamide is approved by the Food and Drug Administration (FDA) to be used by itself or with other drugs to treat the following types of cancer:

• Breast cancer.
• Different types of leukemia, including:
  • Acute lymphoblastic leukemia (ALL) in children.
  • Acute myeloid leukemia (AML).
  • Chronic lymphocytic leukemia (CLL).
  • Chronic myelogenous leukemia (CML).
• Hodgkin lymphoma.
• Multiple myeloma.
• Mycosis fungoides.
• Neuroblastoma.
• Non-Hodgkin lymphoma.
• Ovarian cancer.
• Retinoblastoma.

Cyclophosphamide is also used to treat certain types of nonmalignant kidney disease in children who are not helped by or can no longer take corticosteroids.

Cyclophosphamide is usually used together with other drugs, rather than by itself.

In addition to the uses that have been approved by the FDA, cyclophosphamide is used to treat other types of cancer. The drug continues to be studied in the treatment of many types of cancer.

Definition from the NCI Drug Dictionary - Detailed scientific definition and other names for this drug.

Clinical Trial Results: Less Intense Chemotherapy Effective in Children with Intermediate-Risk Neuroblastoma (06/13/2007) - Important clinical trial results for this drug, background information, and how the trial was done.

Clinical Trial Results: Radiation Might be Avoided for Older Patients with Good Prognosis Non-Hodgkin Lymphoma (02/14/2007) - Important clinical trial results for this drug, background information, and how the trial was done.

Clinical Trial Results: Ovarian Suppression May Be as Effective as Chemotherapy in High-Risk Breast Cancer (12/06/2006) - Important clinical trial results for this drug, background information, and how the trial was done.

Clinical Trial Results: Age and Type of Chemotherapy Affect Women's Chances of Menstruating after Breast Cancer Treatment (02/27/2006) - Important clinical trial results for this drug, background information, and how the trial was done.

MedlinePlus Information on Cyclophosphamide - A lay language summary of important information about this drug that may include the following:

• warnings about this drug,
• what this drug is used for and how it is used,
• what you should tell your doctor before using this drug,
• what you should know about this drug before using it,
• other drugs that may interact with this drug, and
• possible side effects.

Drugs are often studied to find out if they can help treat or prevent conditions other than the ones they are approved for. This NLM patient information sheet applies only to approved uses of the drug. However, much of the information may also apply to unapproved uses that are being studied.

Clinical Trials for Cyclophosphamide - Check for trials from NCI's PDQ Cancer Clinical Trials Registry now accepting patients.

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