Making Scents of the Genome: Functional Genomics of Mammalian Olfaction

 


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Air date: Monday, March 24, 2003, 12:00:00 PM
Category: Neuroscience
Description: NIH Neuroscience Seminar Series

The activity of all cells in the nervous system is regulated by the interaction of various chemicals, such as neurotransmitters, hormones, and peptides with membrane receptors. The ways in which these substances exert their influence is known generally as signal transduction. We use the vertebrate olfactory receptor neuron as a model for investigating general principles and mechanisms of signal transduction - receptor-ligand interactions, modulation by second messeng ers, ion channel gating, and the long term mechanisms of adaptation and desensitization. The olfactory neuron is uniquely suited for these studies since it is designed specifically for the detection and discrimination of a wide variety of small organic molecules, i.e. odors.

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Stuart Firestein
Author: Stuart Firestein, Ph.D., Columbia University
Runtime: 78 minutes
Rights: This is a work of the United States Government. No copyright exists on this material. It may be disseminated freely.
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CIT File ID: 10878
CIT Live ID: 1992
Permanent link: http://videocast.nih.gov/launch.asp?10878