Steven C. Hunt PhD, Marta Gwinn MD, MPH and Ted D. Adams PhD, MPH
Tables
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TABLE 1: Relative risks (95% CI) of CHDa in family members associated with different definitions of positive family history
versus no family history
| 1+ affected, any age |
53% |
2.9 (2.1–3.8) |
1.3 (1.0–1.6) |
1.4 (0.7–2.4) |
1.1 (0.9–1.3) |
| 1+ affected, early ageb |
32% |
3.9 (2.8–5.3) |
1.1 (0.8–1.5) |
2.1 (1.0–3.8) |
1.1 (0.8–1.5) |
| 2+ affected, any age |
24% |
5.9 (2.4–12.1) |
2.0 (0.9–3.7) |
3.3 (0.4–12.1) |
2.1 (1.1–3.6) |
| 2+ affected, early age |
11% |
12.7 (4.7–27.7) |
0.7 (0.1–3.6) |
8.0 (1.0–29.0) |
1.5 (0.3–4.4) |
| Family History Scorec ≥1.0 |
14% |
6.9 (2.8–14.2) |
3.0 (0.8–7.8) |
4.0 (0.5–14.4) |
1.2 (0.3–3.2) |
Note: Adapted from Hunt et al.[13]
CHD, coronary heart disease; CI, confidence interval.
TABLE 2: Family history of CHD and stroke in Health
Family Tree Studya
| CHD |
| ≥0.5 |
14 |
72 |
48 |
| ≥1.0 |
3.2 |
35 |
18 |
| ≥2.0 |
1.0 |
17 |
6 |
| Stroke |
| ≥0.5 |
11 |
86 |
68 |
| ≥1.0 |
1.4 |
22 |
16 |
| ≥2.0 |
1.0 |
19 |
12 |
Note: Adapted from Williams et al.[16]
CHD, coronary heart disease.
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