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Sponsors and Collaborators: |
Weill Medical College of Cornell University Weill Cornell Medical College in Qatar Hamad Medical Corporation |
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Information provided by: | Weill Medical College of Cornell University |
ClinicalTrials.gov Identifier: | NCT00504738 |
The purpose of this protocol is to obtain biologic samples from the blood and lungs from patients with lung diseases in order to study the causes and indications of these disorders, learn how these lung disease manifest and progress, and how the lung disease can be treated.
Condition |
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Lung Disease Chronic Obstructive Pulmonary Disease (COPD) Asthma |
Study Type: | Observational |
Study Design: | Case-Only, Prospective |
Official Title: | Evaluation of the Lungs of Individuals With Lung Disease With Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy (Qatar) |
Estimated Enrollment: | 200 |
Study Start Date: | April 2006 |
The lung diseases are disorders associated with functional and/or structural derangements to the alveolar structures, airways, pulmonary blood vessels, pleura and/or mediastinum. The purpose of this protocol is to obtain biologic materials from the blood and lungs from these patients in order to: (1) develop an understanding of the etiology and pathogenesis of these disorders; and (2) identify individuals who will be suitable candidates for other protocols such as those involving investigational new drugs. As such, this protocol is part of the "infrastructure" for all of our human lung-related studies such as genomic/gene expression studies of airway epithelium and alveolar macrophages in all individuals with chronic obstructive lung disease (COPD), asthma, bronchogenic carcinoma, and pulmonary fibrosis compared to normal non-smokers and smokers, and studies of mediators in bronchoalveolar lavage fluid.
This protocol, to be carried out at Weill Cornell Medical College - Qatar and Hamad Medical Corporation, Qatar, parallels a similar approved protocol IRB #0005004440, entitled, "Evaluation of the Lungs of Individuals with Lung Disease with Segmental Bronchopulmonary Lung Lavage, Bronchial Brushing, and Bronchial Wall Biopsy", ongoing at Weill Cornell Medical College - New York.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Non-Probability Sample |
Recruitment will be from the patients of the Hamad Medical Corporation and others as relevant. The source of potential subjects will be the population of potential subjects with lung disease, as defined by the elegibility criteria, in Qatar. Accrual will be random with no bias as to gender or racial/ethnic group.
Inclusion Criteria:
Inclusion/Exclusion criteria for Part A
Evidence of lung disease by at least one of the following:
Exclusion Criteria:
Patients enrolled in Part A of the protocol will not undergo screening procedures/tests. These patients are undergoing a fiberoptic bronchoscopy as dictated by their standard clinical care and additional samples will be taken for research purposes.
Contact: Charleen Hollmann, PhD, RN | 646-962-2672 | chollman@med.cornell.edu |
Contact: Mary Yeotsas, BA | 646-962-2672 | mey2003@med.cornell.edu |
Qatar | |
Hamad Medical Corporation | Recruiting |
Doha, Qatar | |
Contact: Amani Ma'ayah, MS, Pharm + 974-492-8405 asm2004@qatar-med.cornell.edu | |
Contact: Abeer Gohar, BA + 974-492-8407 abg2004@qatar-med.cornell.edu | |
Principal Investigator: Hisham A Sattar, MD | |
Principal Investigator: Lotfi Chouchane, PhD |
Principal Investigator: | Ronald G. Crystal, MD | Weill Cornell Medical College, New York and Qatar |
Responsible Party: | Weill Cornell Medical College, Department of Genetic Medicine ( Dr. Ronald G. Crystal ) |
Study ID Numbers: | 0604008489, HMC RC392/2006 |
Study First Received: | July 19, 2007 |
Last Updated: | September 15, 2008 |
ClinicalTrials.gov Identifier: | NCT00504738 |
Health Authority: | United States: Institutional Review Board; Qatar: Hamad Medical Corporation Research Committee |
lung disease chronic obstructive pulmonary disease (COPD) asthma smokers non-smokers |
Hypersensitivity Lung Diseases, Obstructive Respiratory Tract Diseases Lung Diseases |
Hypersensitivity, Immediate Asthma Respiratory Hypersensitivity Pulmonary Disease, Chronic Obstructive |
Immune System Diseases Bronchial Diseases |