Genetic Analysis of Hereditary Non-Syndromic Oral Clefts - Full Text View

Sponsored by:	National Human Genome Research Institute (NHGRI)
Information provided by:	National Institutes of Health Clinical Center (CC)
ClinicalTrials.gov Identifier:	NCT00340626

Purpose

In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. The purpose of this study is to identify the gene(s) involved in heritable oral clefts by linkage analysis and gene mapping strategies. Characterization of genes involved in inherited oral clefts could provide important insight into the inheritance and pathogenesis of this disease.

Condition
Hereditary Oral Clefts

MedlinePlus related topics: Cleft Lip and Palate

U.S. FDA Resources

Study Type:	Observational
Official Title:	Genetic Analysis of Hereditary Non-Syndromic Oral Clefts

Further study details as provided by National Institutes of Health Clinical Center (CC):

Estimated Enrollment:	1000
Study Start Date:	June 1997

Detailed Description:

In a collaborative effort with the IBN AL-NAFEES Hospital (Damascus, Syrian Arab Republic), individuals from multiplex families determined to have hereditary oral clefts will be studied. The purpose of this study is to identify the gene(s) involved in heritable oral clefts by linkage analysis and gene mapping strategies. Characterization of genes involved in inherited oral clefts could provide important insight into the inheritance and pathogenesis of this disease.

Eligibility

Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

INCLUSION CRITERIA:

Enrollment in this study will be limited to individuals with non-syndromic unilateral or bilateral cleft lip with or without cleft palate and their unaffected relatives, from families which meet the following criteria:

A cluster of 2 or more affected first degree relatives, such as a parent and two offspring or 2 siblings, or
The occurrence of oral clefts in each of 2 generations in either the proband's paternal or maternal lineages.

EXCLUSION CRITERIA:

Families with syndromic forms of oral clefts.

Individuals unable to provide consent, except for cases who are children and mentally impaired persons with consenting parents or guardians.

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00340626

Contacts

Contact: Joan Bailey-Wilson, Ph.D.

(410) 550-7509

jebw@nhgri.nih.gov

Locations

United States, Massachusetts
Boston University	Recruiting
Boston, Massachusetts, United States, 02118-2354
Syrian Arab Republic
IBN Al Nafees Hospital	Recruiting
Damascus, Syrian Arab Republic

Sponsors and Collaborators

National Human Genome Research Institute (NHGRI)

More Information

Study ID Numbers:	999997035, OH97-HG-N035
Study First Received:	June 19, 2006
Last Updated:	July 18, 2008
ClinicalTrials.gov Identifier:	NCT00340626
Health Authority:	United States: Federal Government

Keywords provided by National Institutes of Health Clinical Center (CC):

Linkage Analysis
Genotyping
Birth Defects
Family Study

Positional Cloning
Non-Syndronic Oral Clefts
Cleft Lip
Cleft Palate

Study placed in the following topic categories:

Cleft Palate
Cleft Lip
Congenital Abnormalities

ClinicalTrials.gov processed this record on January 16, 2009