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Sponsors and Collaborators: |
Dana-Farber Cancer Institute Tehran University of Medical Sciences |
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Information provided by: | Dana-Farber Cancer Institute |
ClinicalTrials.gov Identifier: | NCT00480506 |
The purpose of this study is to collect peripheral blood and bone marrow aspirate samples from thalassemia patients in Tehran, in a collaborative effort to develop an erythroid lineage specific chimerism assay applicable to patients with thalassemia. Development of such an assay would be useful both for identification of the exact mutation causing the disease, as well as for providing a direct method to measure and monitor the kinetics of donor erythropoiesis in this patient population following transplant.
Condition |
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Thalassemia Major |
Study Type: | Observational |
Study Design: | Retrospective |
Official Title: | Monitoring of Erythroid Lineage Specific Chimerism Following Allogeneic Hematopoietic Transplantation for Thalassemia Major |
Estimated Enrollment: | 40 |
Study Start Date: | April 2004 |
Study Completion Date: | October 2005 |
Primary Completion Date: | October 2005 (Final data collection date for primary outcome measure) |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
United States, Massachusetts | |
Dana-Farber Cancer Institute | |
Boston, Massachusetts, United States, 02115 | |
Iran, Islamic Republic of | |
Tehran University of Medical Sciences | |
Tehran, Iran, Islamic Republic of |
Principal Investigator: | Catherine Wu, MD | Dana-Farber Cancer Institute |
Study ID Numbers: | 04-078 |
Study First Received: | May 30, 2007 |
Last Updated: | December 20, 2007 |
ClinicalTrials.gov Identifier: | NCT00480506 |
Health Authority: | United States: Institutional Review Board |
chimerism allogenic hematopoietic transplantation assay |
Anemia, Hemolytic, Congenital Thalassemia minor Genetic Diseases, Inborn Hematologic Diseases Hemoglobinopathies Beta-Thalassemia |
Beta-thalassemia Anemia Anemia, Hemolytic Hemoglobinopathy Thalassemia |