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Study 3 of 155 for search of: | Iran, Islamic Republic of |
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Sponsors and Collaborators: |
Shaheed Beheshti Medical University Tarbiat Modarres University: Department of Hematology |
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Information provided by: | Shaheed Beheshti Medical University |
ClinicalTrials.gov Identifier: | NCT00420134 |
The methods for separation of mesenchymal stem cell were established in 2001. These cells can differentiate to osteocytes, hepatocytes, chondrocytes, myocytes and etc,. In this study we try to separate mesenchymal stem cell from end stage liver disease, then these cells will be differentiated to progenitor of hepatocytes, finally , we injected these cells into portal vein under ultrasound guide. We determine the effects of injected cells in reestablishment of liver function.
Condition | Intervention | Phase |
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Liver Failure Cirrhosis |
Procedure: injection of progenitor of hepatocyte drived from Mesenchymal stem cell |
Phase I Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Single Blind, Historical Control, Single Group Assignment, Safety/Efficacy Study |
Official Title: | A Phase One/Two Clinical Trial on the Use of Autograft Mesenchymal Stem Cells Differentiated Into Progenitor of Hepatocytes for the Salvage Treatment of Patients With End-Stage Liver Disease |
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion criteria:
Exclusion criteria:
Contact: Mohammad Reza Zali, MD | 98-21-2241-8237 ext 102 | info@rcgld.org |
Contact: Pedram Kharaziha, MD | 98-21-2241-8870 | kharaziha@sbmu.ac.ir |
Iran, Islamic Republic of | |
Research center of Gastroenterology and Liver Disease | Recruiting |
Tehran, Iran, Islamic Republic of, 1985711151 | |
Contact: Pedram Kharaziha, MD 98-21-2243-2525 kharaziha@sbmu.ac.ir | |
Research Center for Gastroenterology and Liver Diseases | Recruiting |
Tehran, Iran, Islamic Republic of, 1985711151 | |
Contact: Pedram Kharaziha, MD 98-21-2243-2525 kharaziha@sbmu.ac.ir |
Study Chair: | Mohammad Reza Zali, MD | Research center of Gastroenterology and Liver Disease |
Principal Investigator: | Pedram Kharaziha, MD | Research Center for Gastroenterology and Liver Diseases |
Study ID Numbers: | 348 |
Study First Received: | January 8, 2007 |
Last Updated: | May 20, 2008 |
ClinicalTrials.gov Identifier: | NCT00420134 |
Health Authority: | Iran: Ministry of Health |
mesenchymal stem cell end stage liver disease Cirrhosis stem cell therapy |
Liver Failure Liver Diseases Digestive System Diseases |
Fibrosis Liver Cirrhosis Hepatic Insufficiency |
Pathologic Processes |