The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

Prostate Cancer Susceptibility Loci

Cited Salinas et al. as reference 85 and Robbins et al. as reference 88.

Added text about a study that demonstrated a statistically significant association for four 8q24 variants in prostate cancer risk (cited Cheng et al. as reference 89).

Added text to state that c-MYC is the closest cancer-related gene to the 8q candidate region and may be associated with the overall 8q association findings (cited Salinas et al. as reference 85).

Added text to state that germline mutations in BRCA2 confer a significant increase in risk of prostate cancer among male members of hereditary breast and ovarian cancer families, but that it likely plays only a small role, if any, in site-specific, multiple-case prostate cancer families (cited Ostrander et al. as reference 118).

Added text about a molecular analysis designed specifically to assess the role of seven different CHEK2 coding variants in Ashkenazi Jewish men with prostate cancer, that suggested that germline mutations in this gene have a minor role, if any role at all, in modifying the risk of prostate cancer in Ashkenazi Jewish men (cited Tischkowitz et al. as reference 136).

The Genome-wide Association Studies subsection was extensively revised.

Interventions in Familial Prostate Cancer

This section was extensively revised.

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