[LCMI Membership Roster] [LCMI Meeting Rosters]

The Lung Cellular, Molecular, and Immunobiology [LCMI] Study Section reviews grant applications designed to study the genetic, molecular, and cellular basis of normal respiratory biology, and the alterations in these processes in inflammatory and immune lung disorders.  The study section will consider applications using molecules, cells, tissues, organs, animal models, and/or human investigations that address the identity, function, and products of the cells that populate the airways, the regulation and dysregulation of innate host defense mechanisms and the adaptive immune system in health and disease as they relate to the respiratory system.  Topics may include the inflammatory and immune mechanisms that contribute to the pathogenesis of a variety of airway diseases of the lung, including, but not limited to, Asthma, Cystic Fibrosis, Chronic Obstructive Pulmonary Disease (COPD), and Tuberculosis. Specific areas covered by LCMI:

• Asthma, including: the molecular and cellular mechanisms, pathology and remodeling of airway epithelial cells and airway smooth muscle; cytokine transport and regulation; effects of oxidant and leukotriene products on the airways; T cell secretions and regulation; adrenergic agonists and receptors; and genetic predisposition. 
• Cystic Fibrosis, including molecular mechanisms Cystic Fibrosis Transmembrane Conductance Regulator in airway epithelial cells and bacterial interactions with the airways in Cystic Fibrosis.
• Airway Epithelial Cell Biology, including regulation of secretion of mucins, control of cilia, and development of goblet cell metaplasia.
• Host Defense of the lung, including pulmonary interactions and reactions to aspergillus, influenza, pneumonia, pseudomonas, tuberculosis, rhinovirus, Respiratory Syncytial Virus and other pathogens in the lung. Also, involvement of surfactant proteins A and D in lung host defense:
• Immunology of the lung, including biology, regulation and interactions of alveolar macrophages, T lymphocytes, neutrophils, eosinophils, dendritic cells, mast cells, and B lymphocytes. Also, immunological effects of Lung Transplantation.
• COPD, including the effects of smoking on airway epithelia cells, and airway epithelia cell remodeling in chronic bronchitis.

Study sections with most closely related areas of similar science listed in rank order are:

Lung Injury, Repair, and Remodeling Study Section [LIRR] 
Respiratory Integrative Biology and Translational Research [RIBT] 
Immunity and Host Defense Study Section [IHD] 
Innate Immunity and Inflammation Study Section [III] 
Host Interactions with Bacterial Pathogens Study Section [HIBP]