[MSFE Membership Roster] [MSFE Meeting Rosters]

The Macromolecular Structure and Function E Study Section (MSFE) review applications that focus on the structure and structure-function relationships of enzymes and their complexes. Experimental approaches include the development and application of physical and chemical methods to study interactions between enzymes and their effectors and substrates. Applications evaluated in this study section cover a broad range of theoretical, computational and experimental methods that include but not limited to quantum mechanics, molecular mechanics, kinetic, mechanistic, and thermodynamic characterization of enzymes and their functions. The most commonly used experimental methods are NMR, X-Ray, laser spectroscopy and electron microscopy. The emphasis is on elucidating structure-function relationships of enzymes in their native biological systems.  Specific areas covered by MSFE:

• Mechanistic enzymology involving protein and nucleic acid catalysts.
• Protein-ligand interactions and dynamics.
• Inhibitors of enzymes and their mechanisms, drug chemistry and metabolizing enzymes, biochemical mechanism based drug development.
• Macromolecular studies of metabolic pathways and networks.
• Computational and theoretical studies of biochemical reactions, application of quantum mechanics and molecular mechanics to studies of enzyme mechanisms, genomic enzymology, sequence-structure analysis to uncover mechanistic strategies of superfamilies.

Study sections with most closely related areas of science listed in rank order are:

Macromolecular Structure and Function A [MSFA]
Macromolecular Structure and Function B [MSFB]
Macromolecular Structure and Function C [MSFC]
Macromolecular Structure and Function D [MSFD]
Synthetic and Biological Chemistry A [SBCA]
Synthetic and Biological Chemistry B [SBCB]
Biochemistry and Biophysics of Membranes [BBM]