Laboratory of Genetics |
Intramural Program Investigators ^ Home ^ |
Weidong Wang, Ph.D., Senior Investigator Genome Instability and Chromatin-Remodeling Section |
![]() Research Interests: The establishment and maintenance of transcriptionally active and inactive chromatin structure in higher eucaryotes is key for global gene regulation during development, differentiation and adaptation to environmental stimuli. Evidence accumulated during the last two decades indicates that chromatin structures are remodeled when multipotent precursor cells develop into terminally-differentiated cells. However, the underlying mechanism of chromatin remodeling is poorly understood, primarily because molecules that remodel chromatin structures have been discovered only recently. These complexes can be classified into two different families: one, the histone acetyltransferase or deacetylase complexes which alter the chromatin structure by covalently modifying the tails of histones; the other, the ATP-Dependent Chromatin-Remodeling (ADCR) complexes which use the energy of ATP to disrupt non-covalent DNA-histone contacts. The main focus of our lab is to purify and characterize mammalian ADCR complexes. |
Contact Information: Laboratory of Genetics Biomedical Research Center, 10B133 251 Bayview Boulevard, Suite 100 Baltimore, MD 21224-6825 Phone 410-558-8334 Fax 410-558-8331 E mail wwang@grc.nia.nih.gov For more information about the Laboratory: http://www.grc.nia.nih.gov/branches/lg/trru/trru.htm |
IRP Home What's New Contact Us Accessibility Disclaimer Privacy Site Search Site Map NIA Home |
![]() |
![]() |
![]() |