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Reproducibility of Magnetic Resonance Myocardial Salvage Index
This study has been completed.
Sponsored by: University of Leipzig
Information provided by: University of Leipzig Identifier: NCT00794300

The myocardial salvage assessed by using multimodal cardiac magnetic resonance imaging is a rather new technique which can be used as a surrogate endpoint to reduce the sample size in studies comparing different reperfusion strategies in myocardial infarction. As reproducibility of myocardial salvage has not been evaluated appropriately, we aim to scan 20 patients on 2 subsequent days to evaluate reproducibility of myocardial salvage index.

Condition Intervention
Myocardial Infarction
Device: second magnetic resonance imaging scan

MedlinePlus related topics: Heart Attack MRI Scans Nuclear Scans
U.S. FDA Resources
Study Type: Observational
Study Design: Cohort, Prospective
Official Title: Reproducibility of Myocardial Salvage Index in Acute Myocardial Infarction by Cardiac Magnetic Resonance Imaging

Further study details as provided by University of Leipzig:

Primary Outcome Measures:
  • Myocardial salvage index reproducibility [ Time Frame: 2 days ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • infarct size reproducibility [ Time Frame: 2 days ] [ Designated as safety issue: No ]
  • area at risk reproducibility [ Time Frame: 2 days ] [ Designated as safety issue: No ]
  • microvascular obstruction reproducibility [ Time Frame: 2 days ] [ Designated as safety issue: No ]

Groups/Cohorts Assigned Interventions
Acute myocardial infarction patients Device: second magnetic resonance imaging scan


Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Sampling Method:   Non-Probability Sample
Study Population

ST-elevation myocardial infarction


Inclusion Criteria:

  • ST-elevation myocardial infarction
  • Primary percutaneous coronary intervention

Exclusion Criteria:

  • Contraindications for magnetic resonance imaging
  Contacts and Locations
Please refer to this study by its identifier: NCT00794300

University of Leipzig - Heart Center
Leipzig, Germany, 04289
Sponsors and Collaborators
University of Leipzig
Principal Investigator: Holger Thiele, MD University of Leipzig
  More Information

Study ID Numbers: Repro100
Study First Received: November 19, 2008
Last Updated: November 19, 2008 Identifier: NCT00794300  
Health Authority: Germany: Ethics Commission

Keywords provided by University of Leipzig:
contrast agent
magnetic resonance imaging
infarct size
myocardial salvage index
myocardial salvage assessment

Study placed in the following topic categories:
Heart Diseases
Myocardial Ischemia
Vascular Diseases
Myocardial Infarction

Additional relevant MeSH terms:
Pathologic Processes
Cardiovascular Diseases processed this record on January 13, 2009