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Alternate Title
Basic Trial Information
Trial Description
     Purpose
     Eligibility
     Treatment/Intervention
Trial Contact Information
Registry Information

Alternate Title

Randomized Study of Surveillance For the Early Detection of Lung Cancer in Current or Former Smokers With Mild to Moderate Chronic Obstructive Pulmonary Disease

Basic Trial Information

Phase Type Status Age Sponsor Protocol IDs No phase specified Screening Active Not specified Other CRUK-BRD/06/10 EU-20738, ISRCTN80745975, NCT00512746

Trial Description

Purpose:

Screening tests or exams may help doctors find lung cancer sooner, when it may be easier to treat.

This randomized clinical trial is studying screening tests or exams to see how well they work compared to usual care in finding early stage lung cancer in current or past smokers with chronic obstructive pulmonary disease.

Eligibility:

Eligibility criteria include the following:

• Smokes or smoked (quit smoking within the past 5 years) one pack of cigarettes a day for at least 20 years or two packs a day for at least 10 years
• For more information about the eligibility criteria for this trial, refer to the Health Professional version.

Final eligibility for a clinical trial is determined by the health professionals conducting the trial.

Treatment/Intervention:

Patients will be randomly assigned (have an equal chance of being placed) to one of two groups.

Patients in group one will be evaluated for 5 years. After 5 years, some patients may undergo a chest x-ray.

Patients in group two will undergo screening for lung cancer for 5 years. Blood samples will be collected once a year. Sputum samples will also be collected. Patients with a normal sputum sample will undergo sputum sample collection once a year. Patients with an abnormal sputum sample will undergo a spiral CT scan once a year and bronchoscopy every 4-12 months. If invasive cancer is found, the patient will be referred to their personal doctor for treatment. Any remaining sputum samples will be stored for future laboratory studies.

Important:

For more details about this trial, refer to the Health Professional version of the trial summary.

If you are interested in participating in a clinical trial, contact your doctor for a referral or call a trial contact person listed below. You may see the same contact person listed at more than one site, however, if you call the number listed you can ask to speak to the study coordinator or person involved with the specific trial you are interested in. If you have questions about cancer or clinical trials, call the Cancer Information Service at 1-800-4-CANCER (1-800-422-6237). General information about clinical trials, including risks, benefits, and costs, can be found on NCI's Web site.

Trial Contact Information

Trial Lead Organizations

Cancer Research UK and University College London Cancer Trials Centre

Stephen G. Spiro, Protocol chair		Ph: 44-20-7679-8073

United Kingdom
England
	Cambridge
	Papworth Hospital
		Robert Rintoul, MD	Ph:  44-1480-364-342
			Email: robert.rintoul@papworth.nhs.uk
	Coventry
	Walsgrave Hospital
		Paul Dhillon	Ph:  44-247-696-4000
	Leeds
	Leeds General Infirmary
		Contact Person	Ph:  44-113-243-2799
			Email: paul.plant@leedsth.nhs.uk
	Leicester
	University Hospitals of Leicester NHS Trust
		Mick Peake	Ph:  44-116-287-1471
	London
	Chelsea Westminster Hospital
		Pallav Shah, MD	Ph:  44-20-8746-8000
	Royal Brompton Hospital
		Pallav Shah, MD	Ph:  44-207-352-8121
	University College Hospital - London
		Jeremy George	Ph:  44-207-380-9004
	University College of London Hospitals
		Stephen G. Spiro	Ph:  44-20-7679-8073
	Oxford
	Churchill Hospital
		Mark Slade	Ph:  44-186-574-1841

Registry Information
Official Title		A randomised controlled trial of surveillance for the early detection of lung Cancer in an at risk group [Lung-SEARCH trial]
Trial Start Date		2007-08-24
Trial Completion Date		2009-08-23 (estimated)
Registered in ClinicalTrials.gov		NCT00512746
Date Submitted to PDQ		2007-06-26
Information Last Verified		2008-12-16