Genetic Study of Nephrolithiasis in Gouty Diathesis

This study is currently recruiting participants.

Verified by Mario Negri Institute for Pharmacological Research, June 2007

Sponsored by:	Mario Negri Institute for Pharmacological Research
Information provided by:	Mario Negri Institute for Pharmacological Research
ClinicalTrials.gov Identifier:	NCT00149305

Purpose

Gouty diathesis describes uric acid or calcium oxalate nephrolithiasis and low urinary pH (<5.5). A hereditary component has been outlined for several forms of nephrolithiasis (such as hypercalciuria, hyperoxaluria, cystinuria, renal tubular acidosis), leading to the hypothesis of a genetic predisposition to nephrolithiasis. At the Unit of Nephrology, Ospedali Riuniti di Bergamo, more than 100 patients affected by gouty diathesis are followed. Fifty percent of them has a familiarity for kidney stones formation. The aim of our study is to identify the genetic factors that predispose to the development of nephrolithiasis in patients with gouty diathesis.

Condition
Nephrolithiasis

MedlinePlus related topics: Kidney Stones

U.S. FDA Resources

Study Type:	Observational
Study Design:	Screening, Longitudinal, Defined Population, Prospective Study
Official Title:	Genetic Study of Nephrolithiasis in Gouty Diathesis

Further study details as provided by Mario Negri Institute for Pharmacological Research:

Estimated Enrollment:	100
Study Start Date:	May 2005
Estimated Study Completion Date:	May 2010

Show Detailed Description

Eligibility

Ages Eligible for Study:	10 Years to 85 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes

Criteria

Inclusion Criteria:

male and female, ≥ 10 years of age
uric acid or calcium oxalate nephrolithiasis
urinary 24 h pH < 5.5 in absence of high animal protein intake (urinary sulphate excretion <25 mM/24 h after one week of low animal protein intake)
familial history of kidney stones (at least two first or second degree family members affected)
written informed consent according to the Declaration of Helsinki guidelines

Exclusion Criteria:

renal colic in the 4 weeks preceding evaluations
excessive gastrointestinal alkali loses
inhability to fully understand the purposes of the study or to provide a written informed consent

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00149305

Contacts

Contact: Erica Daina, MD

00390354535304

daina@marionegri.it

Locations

Italy, Bergamo
Clinical Research Center for Rare Diseases	Recruiting
Ranica, Bergamo, Italy, 24020
Contact: Elena Bresin, MD 00390354535304 bresin@marionegri.it

Sponsors and Collaborators

Mario Negri Institute for Pharmacological Research

Investigators

Principal Investigator:

Erica Daina, MD

Mario Negri Institute

More Information

Study ID Numbers:	GOUTY DIATESIS
Study First Received:	September 7, 2005
Last Updated:	June 15, 2007
ClinicalTrials.gov Identifier:	NCT00149305
Health Authority:	Italy: Ministry of Health

Keywords provided by Mario Negri Institute for Pharmacological Research:

Gouty diathesis
Acid uric nephrolitiasis

Study placed in the following topic categories:

Urologic Diseases
Disease Susceptibility
Urolithiasis

Kidney Diseases
Genetic Predisposition to Disease
Nephrolithiasis

ClinicalTrials.gov processed this record on January 16, 2009