Home
Search
Study Topics
Glossary
|
|
|
|
|
|
Sponsored by: |
Hospices Civils de Lyon |
---|---|
Information provided by: | Hospices Civils de Lyon |
ClinicalTrials.gov Identifier: | NCT00149123 |
Major burns trigger the release of circulating mediators, as cytokines and endotoxin that induces a systemic inflammatory response syndrome. The cardiovascular effects are similar to those seen in septic shock. After the initial hypovolemic phase, patients with extensive burns often present a shock with increased cardiac output and reduced systemic vascular resistances. As described in septic shock, we test the hypothesis that low-dose hydrocortisone could decrease the duration of the shock period.
Condition | Intervention | Phase |
---|---|---|
Burns |
Drug: hydrocortisone 200 mg/day |
Phase IV |
Study Type: | Interventional |
Study Design: | Randomized, Double-Blind, Placebo Control, Parallel Assignment |
Official Title: | Low-Dose Hydrocortisone in the Treatment of the Shock of Burned Patients |
Estimated Enrollment: | 40 |
Study Start Date: | April 2005 |
Ages Eligible for Study: | 18 Years to 75 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
Contact: Sylvie TISSOT, MD | 33 4 72 11 75 98 | sylvie.tissot@chu-lyon.fr |
France | |
Sylvie TISSOT | Recruiting |
Lyon, France, 69437 | |
Contact: Sylvie TISSOT, MD 33 4 72 11 75 98 sylvie.tissot@chu-lyon.fr |
Principal Investigator: | Sylvie TISSOT, MD | Hospices Civils de Lyon |
Study ID Numbers: | 2004.354 |
Study First Received: | September 6, 2005 |
Last Updated: | October 4, 2007 |
ClinicalTrials.gov Identifier: | NCT00149123 |
Health Authority: | France: Afssaps - French Health Products Safety Agency |
Burn adrenal insufficiency hydrocortisone short corticotropin test |
Burns Adrenal Insufficiency Hydrocortisone Cortisol succinate Shock |
Hydrocortisone acetate Epinephrine Hypoadrenalism Adrenocorticotropic Hormone Adrenal gland hypofunction |
Anti-Inflammatory Agents Therapeutic Uses Pharmacologic Actions |