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Sponsored by: |
Imperial College London |
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Information provided by: | Imperial College London |
ClinicalTrials.gov Identifier: | NCT00147082 |
The aim of this study is to investigate the mechanisms whereby leukocytes are recruited to the lung in chronic obstructive pulmonary disease (COPD) and cause tissue destruction. The hypothesis is that in COPD more leukocytes enter the lung and it is these cells that are responsible for the degradation of lung tissue. We, the researchers at Imperial College London, will isolate leukocytes from the blood of patients with COPD, healthy smokers and normal subjects and measure the movement of the leukocytes to chemoattractants. We will examine further, which cell surface receptors are responsible for this trafficking of cells. Furthermore, the differentiation of these cells in vitro will be compared with cells from healthy smokers and normal subjects. Specifically, the expression of enzymes that are responsible for tissue destruction and the cell surface receptors on these cells will be investigated. The objective is to identify the mechanisms whereby leukocytes from COPD patients behave differently to cells from healthy smokers and normal subjects with a view to identify novel targets for drug therapy.
Condition |
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COPD Emphysema Chronic Bronchitis |
Study Type: | Observational |
Study Design: | Natural History, Cross-Sectional, Defined Population, Retrospective/Prospective Study |
Official Title: | Leukocyte Migration and Differentiation in COPD Patients Compared to Healthy Smokers and Healthy Non-Smoking Subjects. |
Estimated Enrollment: | 90 |
Study Start Date: | February 2001 |
Estimated Study Completion Date: | April 2005 |
Chemotaxis experiments will be performed in order to ascertain the migratory characteristics of leukocytes towards specific chemoattractants. Comparisons of cells from different subjects will be compared. In addition, the effects of various pharmaceutical interventions on this mechanism will also be addressed and compared within subject groups. In some experiments, cells will be differentiated in vitro and their cellular expression and regulation of inflammatory mediators and chemoattractants examined. Again comparisons will be made between subject groups and the efficacy of various pharmacological agents on these cells
Ages Eligible for Study: | 21 Years to 70 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
Healthy Non-Smoking Subjects. All normal volunteers will meet the following criteria:
COPD Subjects. COPD is diagnosed according to American Thoracic Society, European Respiratory Society and British Thoracic Society guidelines. All COPD volunteers will meet the following criteria:
Healthy Smokers. All healthy smoking volunteers in trials will meet the following criteria:
Exclusion Criteria:
Subjects will not be included in this study if they meet any of the following exclusion criteria:
Contact: Louise E Donnelly, PhD | 0207 352 8121 ext 3061 | l.donnelly@imperial.ac.uk |
United Kingdom | |
Royal Brompton Hospital/NHLI Imperial College London | Recruiting |
London, United Kingdom, SW3 6LY | |
Contact: Louise E Donnelly, PhD |
Principal Investigator: | Louise E Donnelly, PhD | Imperial College London |
Study ID Numbers: | 01-024 |
Study First Received: | September 6, 2005 |
Last Updated: | September 6, 2006 |
ClinicalTrials.gov Identifier: | NCT00147082 |
Health Authority: | United Kingdom: Research Ethics Committee |
chemokine chemokine receptor neutrophil lymphocyte monocyte |
Pulmonary Emphysema Emphysema Bronchitis, Chronic Lung Diseases, Obstructive Respiratory Tract Infections |
Respiratory Tract Diseases Lung Diseases Bronchitis Healthy Pulmonary Disease, Chronic Obstructive |
Pathologic Processes Bronchial Diseases |