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Sponsored by: |
Foundation for Liver Research |
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Information provided by: | Foundation for Liver Research |
ClinicalTrials.gov Identifier: | NCT00146705 |
The aim of this study was to investigate the long term outcome of Peginterferon alpha-2b with or without the addition of lamivudine in patients with chronic hepatitis B
Condition | Intervention |
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Chronic Hepatitis B |
Procedure: blood samples are taken once |
Study Type: | Observational |
Study Design: | Natural History, Longitudinal, Defined Population, Prospective Study |
Official Title: | Long Term Follow-up of Pegylated-Interferon Alpha-2b and Lamivudine Combination Therapy in Patients With Chronic HBV Infection |
Enrollment: | 266 |
Study Start Date: | May 2005 |
Study Completion Date: | September 2006 |
Interferon alpha therapy is a generally accepted agent for the treatment of chronic HBV infection and effective in about one third of patients. Recently, in the HBV 99-01 study, pegylated interferon alpha-2b (PEG-IFN) has been shown to be effective in HBeAg-positive patients with chronic hepatitis B. In this study, 266 patients were randomized to receive PEG-IFN in combination with either lamivudine or placebo for 52 weeks.
Thirty-six percent of patients receiving monotherapy and thirty-five percent receiving combination therapy had lost serum HBeAg at the end of the 26 week post-treatment follow-up period and there was no difference between treatment groups (P = 0.91). More patients on combination therapy initially seroconverted (44% of patients, compared with 29% on monotherapy; P = 0.01) at the end of treatment but relapsed during follow-up. Similar response patterns were seen when response was assessed by DNA suppression and change in ALT levels.
In contrast to nucleoside analogues, such as lamivudine and adefovir dipivoxil, the virological and biochemical response to standard alpha-interferon has been shown to be durable after treatment discontinuation.In addition, standard alpha-interferon leads to improved survival and reduction of hepatocellular carcinoma in chronic hepatitis B patients.Pegylated interferons have shown to be effective in HBeAg-positive chronic hepatitis B patients, but the durability of the response and long-term outcome of treatment have yet to be established.
Ages Eligible for Study: | 18 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Netherlands, dr Molewaterplein 40 | |
University Medical Center Rotterdam | |
Rotterdam, dr Molewaterplein 40, Netherlands, 3015 GD |
Principal Investigator: | Harry LA Janssen, MD PhD | Department of Gastroenterology and Hepatology, University Medical Center Rotterdam, Rotterdam, the Netherlands |
Study ID Numbers: | LTFU HBV 99-01 |
Study First Received: | September 5, 2005 |
Last Updated: | July 31, 2007 |
ClinicalTrials.gov Identifier: | NCT00146705 |
Health Authority: | Netherlands: The Central Committee on Research Involving Human Subjects (CCMO) |
chronic HBV Peginterferon long term follow-up |
Interferon-alpha Liver Diseases Hepatitis, Chronic Interferons Hepatitis, Viral, Human Lamivudine Hepatitis Virus Diseases |
Digestive System Diseases Hepatitis B, Chronic Peginterferon alfa-2b Hepatitis B DNA Virus Infections Interferon Alfa-2a Interferon Alfa-2b |
Anti-Infective Agents Immunologic Factors Antineoplastic Agents Growth Substances Therapeutic Uses Physiological Effects of Drugs |
Growth Inhibitors Angiogenesis Modulating Agents Angiogenesis Inhibitors Antiviral Agents Hepadnaviridae Infections Pharmacologic Actions |