Inclusion Criteria:

1. Ability and willingness to give written informed consent in accordance with institutional and federal guidelines and to comply with the investigational nature of the study and the related requirements.
2. All subjects must have successfully completed participation in a combination TPV/RTV trial or have confirmed virologic failure in the 1182.12 or 1182.48 trial Successful completion of participation is defined as conclusion of required subject weeks on assigned dosing (trial specific) and completion of required visits.
3. Presence of HIV-1 infection as documented by any licensed ELISA test kit and confirmed by Western Blot, or HIV-1 culture, or HIV-1 antigen, or plasma HIV 1 RNA or a second antibody test by a method other than ELISA at any time prior to study entry.
4. Adherence to previous TPV/RTV dosing protocol and adherence to visit requirements of previous protocol (as assessed by principal investigator).

5. Acceptable screening laboratory values that indicate adequate baseline organ function. Laboratory values are considered to be acceptable if the following apply:

   • Total Cholesterol <400 mg/dl (<CTC Grade 2).
   • Total Triglycerides <750 mg/dl (<DAIDS Grade 2).
   • ALT <3.0x ULN and AST <2.5x ULN (<DAIDS Grade 1).
   • Any Grade GGT is acceptable.
   • Any Grade creatinine kinase is acceptable as long as there is no concurrent my opathy.
   • All other laboratory test values <DAIDS Grade 1.

Exclusion Criteria:

1. Female subjects who are of reproductive potential who:

   • Have a positive serum B HCG at Screening/Enrollment Visit.
   • Are not willing to use a reliable method of barrier contraception (such as dia phragm or condoms).
   • Are breast-feeding.
2. Subjects who are actively using injection drugs or other substance abuse (such as extensive alcohol or narcotic use) which is considered by the investigator to be a significant impairment to health and to protocol adherence.
3. Any medical condition(s) which, in the opinion of the investigator, would interfere with the subject's ability to participate in or adhere to the requirements of this protocol.
4. History of any illness or drug allergy which, in the opinion of the investigator, might confound the results of the study or pose additional risk in administering TPV/RTV to the subject.

5. Active use of any of the following:

   • Investigational HIV-1 vaccines.
   • Any new investigational antiretroviral agent that was not approved for use in the patients prior tipranavir trial.
   • Medications excluded during the trial period (see Section 4.2).
   • Herbal medications (e.g., St. John's Wort).

6. Active HIV-related or non HIV-related illness that may be negatively affected by use of TPV/RTV as determined by the investigator.

   - If a subject must temporarily discontinue TPV/RTV at the recommendation of the investigator (at the completion of the previous TPV trial), then the subject may enroll in 1182.17 once the clinical illness has resolved, and after approval from the BI Clinical Monitor or Local Clinical Monitor.

7. Clinically significant liver disease in the 90 days prior to baseline visit, regardless of baseline AST and/or ALT values.
8. Hypersensitivity to TPV or RTV.
9. Voluntary discontinuation of antiretroviral therapy (including TPV/RTV) for more than seven days from completion of previous TPV trial.