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| Sponsored by: |
National Cancer Institute (NCI) |
|---|---|
| Information provided by: | National Cancer Institute (NCI) |
| ClinicalTrials.gov Identifier: | NCT00134121 |
Purpose
RATIONALE: Chemoprevention is the use of certain drugs or supplements to keep cancer from forming, growing, or coming back. The use of omeprazole and amoxicillin and/or vitamin and mineral supplements and/or garlic supplements may prevent stomach cancer.
PURPOSE: This randomized clinical trial is studying how well giving omeprazole and amoxicillin and/or vitamin and mineral supplements and/or garlic supplements works in preventing stomach cancer in patients with precancerous stomach lesions.
| Condition | Intervention |
|---|---|
|
Gastric Cancer Precancerous/Nonmalignant Condition |
Drug: amoxicillin Drug: ascorbic acid Drug: garlic Drug: omeprazole Drug: selenium Drug: vitamin E |
| Study Type: | Interventional |
| Study Design: | Prevention, Randomized, Double-Blind, Placebo Control |
| Official Title: | A Randomized Multi-Intervention Trial to Inhibit Precancerous Lesions in Lindqu, Shandong Province |
Eligibility| Ages Eligible for Study: | 35 Years to 65 Years |
| Genders Eligible for Study: | Both |
| Accepts Healthy Volunteers: | No |
DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS:
Age
Performance status
Life expectancy
Hematopoietic
Hepatic
Renal
Cardiovascular
Pulmonary
Other
PRIOR CONCURRENT THERAPY:
Biologic therapy
Chemotherapy
Endocrine therapy
Radiotherapy
Surgery
Other
Contacts and Locations More Information
| Study ID Numbers: | CDR0000437906, NCI-OH-95-C-N029, BICR-OH95-C-N029 |
| Study First Received: | August 22, 2005 |
| Last Updated: | December 13, 2008 |
| ClinicalTrials.gov Identifier: | NCT00134121 |
| Health Authority: | United States: Federal Government |
|
gastric cancer precancerous/nonmalignant condition |
|
Amoxicillin Tocopherol acetate Digestive System Neoplasms Precancerous Conditions Gastrointestinal Diseases Omeprazole Stomach cancer Alpha-Tocopherol |
Tocopherols Selenium Vitamin E Digestive System Diseases Stomach Diseases Stomach Neoplasms Gastrointestinal Neoplasms Ascorbic Acid |
|
Anti-Infective Agents Antioxidants Molecular Mechanisms of Pharmacological Action Growth Substances Physiological Effects of Drugs Gastrointestinal Agents Enzyme Inhibitors Protective Agents |
Pharmacologic Actions Anti-Bacterial Agents Neoplasms Neoplasms by Site Therapeutic Uses Vitamins Anti-Ulcer Agents Micronutrients |
