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Sponsored by: |
National Institute on Drug Abuse (NIDA) |
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Information provided by: | National Institute on Drug Abuse (NIDA) |
ClinicalTrials.gov Identifier: | NCT00687713 |
This study is to assess the efficacy of bupropion in reducing methamphetamine use in subjects with methamphetamine dependence who report using methamphetamine 18 or less days during the 30 days prior to the start of signing consent.
Condition | Intervention | Phase |
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Methamphetamine Dependence |
Drug: Bupropion Other: Placebo |
Phase II |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double Blind (Subject, Caregiver, Investigator), Placebo Control, Parallel Assignment |
Official Title: | Phase 2, Double-Blind, Placebo-Controlled Trial of Bupropion for Methamphetamine Dependence |
Estimated Enrollment: | 150 |
Study Start Date: | May 2008 |
Estimated Study Completion Date: | December 2010 |
Estimated Primary Completion Date: | June 2009 (Final data collection date for primary outcome measure) |
Arms | Assigned Interventions |
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1: Experimental |
Drug: Bupropion
150mg for the first 3 days of dosing. Increased to 150 mg b.i.d until taper.
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2: Placebo Comparator |
Other: Placebo
Placebo
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Ages Eligible for Study: | 18 Years to 65 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
Exclusion Criteria:
United States, California | |
Addiction Phrmacology Research Laboratory | Recruiting |
San Fransisco, California, United States, 94110 | |
Contact: Gannt Galloway, Pharm.D. 415-641-3370 | |
Principal Investigator: Gannt Galloway, Pharm.D. | |
UCLA Integrated Substance Abuse Program | Recruiting |
Los Angeles, California, United States, 90025 | |
Contact: Richard A Rawson, Ph.D. 310-445-0874 ext 311 | |
Principal Investigator: Richard A Rawson, Ph.D. | |
United States, New York | |
New York University | Recruiting |
New York, New York, United States, 10010 | |
Contact: Malcolm Reid, Ph.D. 212-686-7500 | |
Principal Investigator: Malcolm Reid, Ph.D. | |
United States, South Carolina | |
Medical University of South Carolina | Recruiting |
Charleston, South Carolina, United States, 29425 | |
Contact: Robert Malcolm, MD 843-792-5214 | |
Principal Investigator: Robert Malcolm, M.D. | |
United States, Texas | |
University of Texas Health Science At San Antonio | Recruiting |
San Antonio, Texas, United States, 78229-3900 | |
Contact: John D Roache, Ph.D. 210-562-5401 | |
Principal Investigator: John D. Roache, Ph.D. |
Responsible Party: | National Institute on Drug Abust (NIDA) ( Liza Gorgon ) |
Study ID Numbers: | MDS Bupropion Meth 0001 |
Study First Received: | May 29, 2008 |
Last Updated: | May 29, 2008 |
ClinicalTrials.gov Identifier: | NCT00687713 |
Health Authority: | United States: Food and Drug Administration; United States: Institutional Review Board |
Methamphetamine Dopamine Bupropion Amphetamine |
Dopamine Uptake Inhibitors Neurotransmitter Uptake Inhibitors Neurotransmitter Agents Molecular Mechanisms of Pharmacological Action Adrenergic Agents Sympathomimetics Adrenergic Uptake Inhibitors Physiological Effects of Drugs Psychotropic Drugs |
Central Nervous System Stimulants Pharmacologic Actions Autonomic Agents Therapeutic Uses Dopamine Agents Peripheral Nervous System Agents Antidepressive Agents, Second-Generation Central Nervous System Agents Antidepressive Agents |