Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools - Full Text View

Sponsored by:	Laval University
Information provided by:	Laval University
ClinicalTrials.gov Identifier:	NCT00686452

Purpose

Swimmers show the highest prevalence of asthma among elite athletes, certainly due to chlorine exposure. The consequences of a chronic exposure to chlorine compounds by swimmers and the mechanisms of asthme in this population are still poorly documented. Specific diagnostic criteria have been proposed by the International Olympic Committee - Medical Council (IOC-MC) and World anti-doping agency (WADA) to determine the presence of asthma in athletes. Using the more specific bronchial provocation tests, our aims are

to compare the prevalence of asthma in swimmers and control subjects
to analyze the Influence of chlorine exposure on bronchial inflammatory processes in swimmers versus control subjects
to study the time-course of changes in airway symptoms, responsiveness, inflammation and remodeling after cessation of training

Condition
Asthma Airway Hyperresponsiveness

MedlinePlus related topics: Asthma

U.S. FDA Resources

Study Type:	Observational
Study Design:	Case Control, Prospective
Official Title:	Airway Dysfunction and Remodelling in Athletes Following Swimming Training in Chlorinated Pools

Further study details as provided by Laval University:

Primary Outcome Measures:

Asthma and airway hyperreactivity prevalence in swimmers [ Time Frame: 3 measurements in the year ] [ Designated as safety issue: No ]

Secondary Outcome Measures:

Airway inflammation and remodeling in swimmers [ Time Frame: 3 measurements in the year and a bronchial biopsy ] [ Designated as safety issue: No ]

Biospecimen Retention: Samples With DNA

Biospecimen Description:

Serum, plasma, bronchial biopsies

Estimated Enrollment:	100
Study Start Date:	March 2007
Estimated Study Completion Date:	May 2009
Estimated Primary Completion Date:	May 2009 (Final data collection date for primary outcome measure)

Groups/Cohorts
1 Swimmers without AHR
2 Swimmers with asymptomatic AHR
3 Swimmers with symptomatic AHR and use only of beta-2 adrenargic
4 Swimmers with asthma and inhaled corticosteroids
5 Healthy Subjects
6 Healthy subjects with AHR
7 Healthy subjects with symptomatic AHR (asthma) but without treatment

Eligibility

Ages Eligible for Study:	14 Years to 35 Years
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	Yes
Sampling Method:	Non-Probability Sample

Study Population

Swimmers from Quebec swimming school and universities Control from université Laval or secondary School

Criteria

Inclusion Criteria:

14 to 35 years old
To swim at least 10h per week
For control subjects, non-competitive healthy subjects

Exclusion Criteria:

any disease that may interfere with the tests for the controls
Triathletes are excluded
Smokers
Obese or with a BMI more than 29
Former athletes (control group)

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00686452

Contacts

Contact: Valérie BOUGAULT, PhD	418-656-8711 ext 1507	valerie.bougault@crhl.ulaval.ca
Contact: Louis-Philippe BOULET, MD	418-656-4747	lpboulet@crhl.ulaval.ca

Locations

Canada, Quebec
Centre de recherche en pneumologie et en cardiologie de l'hôpital Laval	Recruiting
Québec, Quebec, Canada, G1V4G5
Contact: Valerie BOUGAULT, PhD 418-656-8711 ext 1507 valerie.bougault@crhl.ulaval.ca
Contact: Louis-Philippe BOULET, MD lpboulet@crhl.ulaval.ca
Principal Investigator: Louis-Philippe BOULET, MD

Sponsors and Collaborators

Laval University

More Information

Responsible Party:	Hôpital Laval ( Dr Louis-Philippe BOULET, MD )
Study ID Numbers:	CER20159
Study First Received:	May 26, 2008
Last Updated:	December 18, 2008
ClinicalTrials.gov Identifier:	NCT00686452
Health Authority:	Canada: Canadian Institutes of Health Research

Keywords provided by Laval University:

Asthma
Airway hyperresponsiveness
Swimmers
Airway inflammation
Airway remodelling

Study placed in the following topic categories:

Hypersensitivity
Lung Diseases, Obstructive
Respiratory Tract Diseases
Lung Diseases

Hypersensitivity, Immediate
Asthma
Respiratory Hypersensitivity
Inflammation

Additional relevant MeSH terms:

Immune System Diseases
Bronchial Diseases

ClinicalTrials.gov processed this record on January 16, 2009