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Sponsored by: |
National Institute on Aging (NIA) |
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Information provided by: | National Institute on Aging (NIA) |
ClinicalTrials.gov Identifier: | NCT00752271 |
The purpose of this study is to examine the relationship between muscle activation and heart rate on joint generalized inflammation and arthritis development.
Condition |
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Osteoarthritis |
Study Type: | Observational |
Study Design: | Case Control, Prospective |
Official Title: | Inflammatory and Biomechanical Contributors to Arthritis Development Following Arthroscopic Meniscectomy |
Estimated Enrollment: | 32 |
Study Start Date: | May 2008 |
Estimated Study Completion Date: | May 2010 |
Estimated Primary Completion Date: | May 2010 (Final data collection date for primary outcome measure) |
Groups/Cohorts |
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1
24 adults with meniscal damage for which arthroscopy is clinically indicated
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2
8 adults who have already undergone meniscal resection to serve as positive controls
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This study will test the hypothesis that knee trauma (as exemplified by the arthroscopy procedure) causes inflammation that alters muscle activation patterns locally and also disrupts the balance between parasympathetic-sympathetic reflexes. It is hypothesized that these factors contribute to development and progression of knee osteoarthritis.
Ages Eligible for Study: | 40 Years and older |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | Yes |
Sampling Method: | Non-Probability Sample |
Orthopedic and arthritis clinics in the Baltimore/Washington DC area
Inclusion Criteria:
Exclusion Criteria:
Contact: Clinical Research Coordinator | 410-350-7319 or 410-350-3955 | schaffnervl@mail.nih.gov |
Contact: NIA Clinical Research Recruiting Office | 410-350-3941 | NIAStudiesRecruitment@mail.nih.gov |
United States, Maryland | |
NIA Clinical Research Unit | Recruiting |
Baltimore, Maryland, United States, 21225 |
Principal Investigator: | Shari M. Ling, MD | National Institute on Aging (NIA) |
Responsible Party: | National Institute on Aging ( Shari M. Ling, MD ) |
Study ID Numbers: | AG0105 |
Study First Received: | September 11, 2008 |
Last Updated: | September 11, 2008 |
ClinicalTrials.gov Identifier: | NCT00752271 |
Health Authority: | United States: Federal Government |
Arthroscopic |
Musculoskeletal Diseases Osteoarthritis Joint Diseases Arthritis Rheumatic Diseases |