Uremic Toxins in the Intensive Care Unit (ICU): Patients With Sepsis - Full Text View

Sponsored by:	University Hospital, Ghent
Information provided by:	University Hospital, Ghent
ClinicalTrials.gov Identifier:	NCT00752245

Purpose

Study of the kinetics of uremic toxins in the ICU patients with acute renal failure, in order to optimize the dialysis dose: patients with sepsis/multi-organ failure. The sampling of blood and dialysate will be done during dialyses with different durations (4, 6 and 8h)

Condition	Intervention
Renal Failure Multi Organ Failure	Procedure: Dialysis during 4 hours Procedure: Dialysis during 6 hours Procedure: Dialysis during 8 hours

MedlinePlus related topics: Kidney Failure Sepsis

U.S. FDA Resources

Study Type:	Interventional
Study Design:	Treatment, Randomized, Open Label, Active Control, Crossover Assignment, Efficacy Study
Official Title:	Study of the Kinetics of Uremic Toxins in the ICU Patients With Acute Renal Failure, in Order to Optimize the Dialysis Dose: Patients With Sepsis/Multi-Organ Failure

Further study details as provided by University Hospital, Ghent:

Primary Outcome Measures:

Registration of toxin removal efficiency [ Time Frame: During dialysis ] [ Designated as safety issue: No ]

Estimated Enrollment:	12
Study Start Date:	September 2008
Estimated Study Completion Date:	December 2009
Estimated Primary Completion Date:	December 2009 (Final data collection date for primary outcome measure)

Arms	Assigned Interventions
1: Experimental Dialysis during 4 hours	Procedure: Dialysis during 4 hours Blood and dialysate sampling
2: Active Comparator Dialysis during 6 hours	Procedure: Dialysis during 6 hours Blood and dialysate sampling
3: Active Comparator Dialysis during 8 hours	Procedure: Dialysis during 8 hours Blood and dialysate sampling

Eligibility

Ages Eligible for Study:	18 Years and older
Genders Eligible for Study:	Both
Accepts Healthy Volunteers:	No

Criteria

Inclusion Criteria:

ICU patients with sepsis/multi-organ failure with acute renal failure

Contacts and Locations

Please refer to this study by its ClinicalTrials.gov identifier: NCT00752245

Contacts

Contact: Sunny Eloot, PhD

Sunny.eloot@ugent.be

Locations

Belgium
University Hospital Ghent	Recruiting
Ghent, Belgium, 9000
Principal Investigator: Raymond Vanholder, MD, PhD
Sub-Investigator: Sunny Eloot, PhD

Sponsors and Collaborators

University Hospital, Ghent

Investigators

Principal Investigator:

Raymond Vanholder, MD, PhD

University Hospital, Ghent

More Information

Website of the University Hospital Ghent This link exits the ClinicalTrials.gov site

Responsible Party:	University Hospital Ghent ( Raymond Vanholder )
Study ID Numbers:	2008/373
Study First Received:	September 12, 2008
Last Updated:	September 12, 2008
ClinicalTrials.gov Identifier:	NCT00752245
Health Authority:	Belgium: Institutional Review Board

Keywords provided by University Hospital, Ghent:

ICU patients with acute renal failure with sepsis/multi-organ failure

Study placed in the following topic categories:

Renal Insufficiency
Sepsis
Shock
Urologic Diseases
Multiple Organ Failure

Renal Insufficiency, Acute
Kidney Diseases
Kidney Failure, Acute
Kidney Failure

Additional relevant MeSH terms:

Pathologic Processes

ClinicalTrials.gov processed this record on January 16, 2009