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Sponsored by: |
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
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Information provided by: | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) |
ClinicalTrials.gov Identifier: | NCT00069134 |
It is believed that the organs of severely malnourished children malfunction because harmful compounds called oxidants injure the tissues in these organs. In a healthy person oxidants are made harmless because another compound called glutathione neutralizes them. Glutathione is made from three amino acids that we get from the protein we eat in our food. We found that malnourished children were not making enough glutathione because they lacked one of these amino acids called cysteine. In this study we determine why malnourished children do not have sufficient cysteine, and we will feed malnourished children a whey-based diet which is rich in cysteine during their treatment to determine whether they will make more glutathione. This in turn may make their organs recover faster. These findings will let us know whether malnourished children can recover faster if they are given more cysteine during the early phase of treatment.
Condition | Intervention | Phase |
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Protein-Energy Malnutrition Kwashiorkor Marasmus |
Behavioral: cysteine-rich whey based formula |
Phase I |
Study Type: | Interventional |
Study Design: | Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study |
Official Title: | Glutathione Homeostasis and Oxidant Damage in Kwashiorkor |
Ages Eligible for Study: | 6 Months to 18 Months |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Contact: Marvin Reid, MBBS, Ph.D. | 876-702-4729 | marvin.reid@uwimona.edu.jm |
Contact: Asha Badaloo, Ph.D. | 876-702-4421 | asha.badaloo@uwimona.edu.jm |
Jamaica, Saint Andrew | |
Tropical Metabolism Research Unit, University of the West Indies | Recruiting |
Kingston, Saint Andrew, Jamaica, Kingston-7 | |
Contact: Terrence Forrester, M.D., Ph.D. 876-702-4687 terrence.forrester@uwimona.edu.jm | |
Contact: Marvin Reid, MB.BS, Ph.D. 876-702-4729 marvin.reid@uwimona.edu.jm | |
Principal Investigator: Terrence Forrester, M.D., Ph.D. |
Principal Investigator: | Farook Jahoor, Ph.D. | Baylor College of Medicine |
Study ID Numbers: | GLUTH - dk56689 |
Study First Received: | September 15, 2003 |
Last Updated: | October 9, 2007 |
ClinicalTrials.gov Identifier: | NCT00069134 |
Health Authority: | United States: Federal Government |
glutathione kinetics oxidant damage anti-oxidant capacity |
oxidative stress cysteine kinetics severe childhood malnutrition |
Protein Deficiency Malnutrition Nutrition Disorders Stress |
Kwashiorkor Protein-Energy Malnutrition Deficiency Diseases |