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Sponsored by: |
National Heart, Lung, and Blood Institute (NHLBI) |
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Information provided by: | National Heart, Lung, and Blood Institute (NHLBI) |
ClinicalTrials.gov Identifier: | NCT00461227 |
Asthma is a major public health problem among Puerto Ricans. Little is known, however, about the effect of heredity and environment on the development and severity of asthma in this population. This study will examine the relationship between asthma and certain genetic and environmental factors in Puerto Rican children.
Condition |
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Asthma Hypersensitivity |
Study Type: | Observational |
Study Design: | Case Control, Cross-Sectional |
Official Title: | Genes, Home Allergens, and Asthma in Puerto Rican Children |
Serum
Estimated Enrollment: | 1000 |
Study Start Date: | August 2006 |
Estimated Study Completion Date: | July 2011 |
Asthma is a chronic disease that causes constriction of the airways. People with asthma may experience wheezing, coughing, chest tightness, and trouble breathing. Although asthma is a major public health problem among Puerto Ricans, little research has been done to determine the influence of heredity and environment on the disease in this population. To learn more about these relationships, this study will examine the effects of certain genes and allergens on the development and severity of asthma in Puerto Rican children.
This observational study will recruit both children with asthma and children without asthma. Participants will meet with study staff twice during the study. The first visit will take place at participants' homes. Participants will complete questionnaires about demographics, respiratory and general health, and household characteristics. Lung function testing, collection of blood samples, and collection of household dust samples will also take place at the home-based visit. The second visit will take place at the study site. At this visit, participants will undergo allergy tests on the skin and a methacholine challenge test to assess their airway responsiveness and asthma severity. The methacholine challenge test will involve inhaling mist through a mouthpiece and blowing forcefully into a special apparatus called a spirometer. Parents will be asked to provide information about their children's exposure to pets in early life. Each visit will last approximately 1.5 hours and will be scheduled close to the date on which a participant enters the study.
Ages Eligible for Study: | 6 Years to 17 Years |
Genders Eligible for Study: | Both |
Accepts Healthy Volunteers: | No |
Sampling Method: | Probability Sample |
Children of Puerto Rican descent (having four Puerto Rican grandparents) who attend public schools in the city of Hartford, Connecticut.
Inclusion Criteria:
For participants with asthma:
For participants without asthma:
Exclusion Criteria:
Contact: Juan C. Celedon, MD, DrPH | juan.celedon@channing.harvard.edu | |
Contact: Michelle M. Cloutier, MD | Mclouti@ccmckids.org |
United States, Connecticut | |
Connecticut Children's Medical Center | Recruiting |
Hartford, Connecticut, United States, 06106 | |
Contact: Michelle M. Cloutier, MD Mclouti@ccmckids.org | |
Principal Investigator: Michelle M. Cloutier, MD |
Principal Investigator: | Juan C. Celedon, MD, DrPH | Brigham and Women's Hospital |
Responsible Party: | Brigham and Women's Hospital, Harvard Medical School ( Juan C. Celedon, M.D., Dr.P.H. (Principal Investigator) ) |
Study ID Numbers: | 1353, R01 HL079966-01A2 |
Study First Received: | April 13, 2007 |
Last Updated: | July 28, 2008 |
ClinicalTrials.gov Identifier: | NCT00461227 |
Health Authority: | United States: Federal Government |
Puerto Rican Allergies |
Lung Diseases, Obstructive Hypersensitivity Respiratory Tract Diseases Lung Diseases |
Hypersensitivity, Immediate Asthma Respiratory Hypersensitivity |
Immune System Diseases Bronchial Diseases |